Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.
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Summary
The results suggest that the STE6 protein in yeast, and possibly mdr in animals, is a transmembrane translocator that exports polypeptides by a route independent of the classical secretory pathway.
- Type
- article
- Published
- 1989-12-01
- Cited by
- 417
- References
- 56
- OpenAlex
- https://openalex.org/W131157789
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31301642
Keywords
Biology, Permease, Saccharomyces cerevisiae, Gene product, Plasmid
References
- Molecular characterization of the oligopeptide permease of Salmonella typhimurium.
- Sequencing end-labeled DNA with base-specific chemical cleavages.
- The human mdr3 gene encodes a novel P‐glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.
- Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis.
- Protein transport and secretion
- Nucleotide binding by membrane components of bacterial periplasmic binding protein‐dependent transport systems.
- ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells
- Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.
- Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.
- One-step gene disruption in yeast.
- Laboratory course manual for methods in yeast genetics
- Secretion of cyclolysin, the calmodulin‐sensitive adenylate cyclase‐haemolysin bifunctional protein of Bordetella pertussis.
- Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae
- Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae
- Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones
- Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae.
- The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell.
- Nucleotide sequence of an Escherichia coli chromosomal hemolysin
- Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein
- The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
Cited by
- Secretion across the bacterial outer membrane.
- Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M‐factor and isolation and analysis of two genes encoding the pheromone.
- Classification of membrane transporters.
- P-glycoprotein homologues.
- A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis.
- Functional Dissection of P-glycoprotein Nucleotide-binding Domains in Chimeric and Mutant Proteins
- ABC transporters: bacterial exporters
- A novel a-factor-related peptide of Saccharomyces cerevisiae that exits the cell by a Ste6p-independent mechanism.
- Prolyl isomerases in yeast.
- Genomic Convergence toward Diploidy in Saccharomyces cerevisiae
- Proteolytic processing of certain CaaX motifs can occur in the absence of the Rce1p and Ste24p CaaX proteases
- Protein Multifunctionality: Principles and Mechanisms
- Mutational analysis of the yeast a‐factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.
- The CF gene product as a member of a membrane transporter (TM6-NBF) super family.
- ABC transporters and multidrug resistance in Aspergillus nidulans
- THE ROLE OF CYTOPLASMIC CHAPERONES IN THE BIOGENESIS, MATURATION, AND DEGRADATION OF CYTOPLASMIC AND INTEGRAL MEMBRANE PROTEINS
- A new class of proteins capable of binding transition metals
- The impact of multiple drug resistance (MDR) proteins on chemotherapy and drug discovery.
- Components and mechanisms involved in transport of proteins into the endoplasmic reticulum.
- A novel secretory pathway for interleukin‐1 beta, a protein lacking a signal sequence.
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