Non-myeloablative hematopoietic stem cell transplantation (NST) in the treatment of human malignancies: from animal models to clinical practice.
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Summary
Existing clinical data suggest that NST does limit the incidence and severity of GVHD, and preliminary animal models using costimulation blockade for specific induction of tolerance are promising steps towards achievement of this goal.
- Type
- review
- Published
- 2002-01-01
- Cited by
- 8
- References
- 68
- OpenAlex
- https://openalex.org/W123830139
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32620886
Keywords
Stem cell, Transplantation, Hematopoietic stem cell transplantation, Medicine, Haematopoiesis
References
- Permanent and specific transplantation tolerance induced by a nonmyeloablative treatment to a wide variety of allogeneic tissues: I. Induction of tolerance by a short course of total lymphoid irradiation and selective elimination of the donor-specific host lymphocytes.
- Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases.
- Progress in bone marrow transplantation
- Graft-versus-myeloma effect: proof of principle.
- Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.
- Update: Antigen Presentation: A Balanced Diet
- Graft-versus-leukemia reactions after bone marrow transplantation.
- Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy.
- Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation.
- Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation.
- Cytokine dysregulation and acute graft-versus-host disease.
- Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients.
- Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling
- Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
- Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients.
- Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines.
- Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses.
- Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.
- Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies.
- Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant.
Cited by
- Results of a phase I/II British Society of Bone Marrow Transplantation study on PCR-based pre-emptive therapy with valganciclovir or ganciclovir for active CMV infection following alemtuzumab-based reduced intensity allogeneic stem cell transplantation.
- Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP)
- Results of genoidentical hemopoietic stem cell transplantation with reduced intensity conditioning for acute myelocytic leukemia: higher doses of stem cells infused benefit patients receiving transplants in second remission or beyond--the Acute Leukemia Working Party of the European Cooperative Grou
- Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant.
- WT1‐specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation
- Biomarkers in graft versus host disease after allogeneic hematopoietic stem cell transplant
- EXHALED NITRIC OXIDE AND PULMONARY COMPLICATIONS AFTER ALLOGENEIC STEM CELL TRANSPLANTATION
- The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party
- UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL FACULDADE DE MEDICINA PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA: CIÊNCIAS MÉDICAS VALIDAÇÃO DO ESCORE DE RISCO DO EBMT (EUROPEAN GROUP FOR BLOOD AND MARROW TRANSPLANTATION) NA POPULAÇÃO DE PACIENTES SUBMETIDOS AO TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOÉTICAS NO HOSPITAL DE CLÍNICAS DE PORTO ALEGRE
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