Investigating the molecular mechanism of Shroom-Rock interaction and its role in cellular and tissue morphogenesis
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Summary
The surface patches of highly conserved residues in Rock SBD that are important for Shroom binding, co-localization with Shroom, and apical constriction of MDCK cells are identified and facilitated a better understanding of the dynamics of Shroom-Rock interaction and ultimately cell morphogenesis.
- Type
- article
- Published
- 2014-05-28
- Cited by
- 0
- References
- 386
- Access
- Open access
- OpenAlex
- https://openalex.org/W116183435
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81017954
Keywords
Morphogenesis, Cell biology, Apical constriction, Myosin, Cytoskeleton
References
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- Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
- Smooth muscle calponin. Inhibition of actomyosin MgATPase and regulation by phosphorylation.
- Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
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- The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
- Structure of Cdc42 bound to the GTPase binding domain of PAK
- CRMP-2 induces axons in cultured hippocampal neurons
- Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK‐I and ROCK‐II
- Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin.
- Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP).
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