Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens.

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Summary

It is concluded that tryptase induces VPE by releasing BK, primarily through prekallikrein activation, but also through direct release from kininogens, which indicates that this mast cell-derived proteinase contributes to kinin production in allergic diseases.

Type
article
Published
1996-05-01
Cited by
103
References
0

Keywords

Tryptase, Prekallikrein, Kininogen, High-molecular-weight kininogen, Chemistry

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