RETINAL INSULIN RECEPTOR SIGNALING IN HYPEROSMOTIC STRESS
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Summary
The IR signaling in sorbitol-induced hyperosmotic stressed retinas is examined to rescue retinal neurons from apoptosis through a phosphoinositide 3-kinase and protein kinase B (Akt) survival cascade.
- Type
- article
- Published
- 2009-01-01
- Cited by
- 12
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W96184983
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39474230
Keywords
Neurodegeneration, Retina, Insulin receptor, Cell biology, Protein kinase B
References
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- Role of sorbitol pathway in neuropathy.
- Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS.
- Complications
- Increase of protein tyrosine phosphorylation in rat retina after ischemia-reperfusion injury.
- The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120
- Genistein, a protein tyrosine kinase inhibitor, ameliorates retinal degeneration after ischemia-reperfusion injury in rat.
- Dopamine Induces a PI3-Kinase-Independent Activation of Akt in Striatal Neurons: A New Route to cAMP Response Element-Binding Protein Phosphorylation
- Localization of the insulin receptor in caveolae of adipocyte plasma membrane
- Aldose reductase and its inhibition in the control of diabetic complications.
- Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases.
- Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules.
- The sorbitol pathway and the complications of diabetes.
- The gift of Gab
- Hyperosmotic stress activates the insulin receptor in CHO cells.
- Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells*
- Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway*
- Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3*
- Plasma Endothelin-1 Levels in Obese Hypertensive and Normotensive Men
- Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat
Cited by
- Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats
- The CRB1 and adherens junction complex proteins in retinal development and maintenance.
- Phosphoinositide 3-kinase signaling in the vertebrate retina
- Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.
- The Role of Insulin-Like Growth Factor-I in the Physiopathology of Hearing
- Role of sorbitol-mediated cellular stress response in obesity-associated retinal degeneration.
- Nrn1 Overexpression Attenuates Retinal Ganglion Cell Apoptosis, Promotes Axonal Regeneration, and Improves Visual Function Following Optic Nerve Crush in Rats
- Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy
- Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy
- Signaling roles of phosphoinositides in the retina and Lipid-Soluble Molecules in the Eye
- Molecular Neuroscience Mini Review Article the Role of Insulin-like Growth Factor-i in the Physiopathology of Hearing
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