ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.

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Summary

The results suggest that the rhoA gene product plays a critical role in G1-S progression in cultured Swiss 3T3 cells and that the ADP-ribosylation abolishes this activity and causes the cells to accumulate in G 1 phase of the cell cycle.

Type
article
Published
1993-06-01
Cited by
200
References
0

Keywords

Exoenzyme, RHOA, Biology, Cell cycle, ADP-ribosylation

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