Two-dimensional vs. three-dimensional in vitro tumor migration and invasion assays.
Explore this paper's citation graph
Summary
This chapter aims to give an overview of some commonly used migration and invasion assays to aid in the selection of a balanced portfolio of techniques for the rapid and accurate evaluation of novel therapeutic agents.
- Type
- article
- Published
- 2013-01-01
- Cited by
- 39
- References
- 133
- OpenAlex
- https://openalex.org/W89612929
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22957797
Keywords
Angiogenesis, Metastasis, Cancer research, Motility, In vivo
References
- The Use of 3-D Cultures for High-Throughput Screening: The Multicellular Spheroid Model
- A novel 3‐dimensional culture system as an in vitro model for studying oral cancer cell invasion
- Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression
- Morphological changes and molecular expressions of hepatocellular carcinoma cells in three-dimensional culture model.
- Development of a drug resistance model for hepatoblastoma.
- Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway
- 3D cell culture: a review of current approaches and techniques.
- Transwell(®) invasion assays.
- Cell migration into a wounded area in vitro.
- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance.
- Functional screening with a live cell imaging-based random cell migration assay.
- Quantitative high throughput endothelial cell migration and invasion assay system.
- Cell migration/invasion assays and their application in cancer drug discovery.
- Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
- An in vitro assay to assess uveal melanoma invasion across endothelial and basement membrane barriers.
- Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression.
- Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro.
- Evaluation of endothelial cell migration with a novel in vitro assay system.
- Phosphoinositide 3-Kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis
- A new direct-viewing chemotaxis chamber.
Cited by
- A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells
- Digital Microfluidic Lab-on-a-Chip Platform for the Culture and Analysis of Three-Dimensional Multicellular Spheroids
- Migratory behaviour of tumour cells: a scanning electron microscopy study.
- Wnt signalling in the Ewing’s sarcoma family of tumours
- 3D cell culture systems modeling tumor growth determinants in cancer target discovery.
- Three-Dimensional (3D) Tumor Spheroid Invasion Assay
- The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration.
- Drug discovery through stem cell-based organoid models.
- Ring cell migration assay identifies distinct effects of extracellular matrix proteins on cancer cell migration
- A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier
- Digital microfluidics for spheroid-based invasion assays.
- Dissecting brain tumor growth and metastasis in vitro and ex vivo
- Computer-assisted quantification of motile and invasive capabilities of cancer cells
- Roles of different IRES-dependent FGF2 isoforms in the acquisition of the major aggressive features of human metastatic melanoma
- A Novel Computer-Assisted Approach to evaluate Multicellular Tumor Spheroid Invasion Assay
- 3D tumor spheroids: an overview on the tools and techniques used for their analysis.
- Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer
- An Efficient and Flexible Cell Aggregation Method for 3D Spheroid Production.
- A multiscale model for heterogeneous tumor spheroid in vitro.
- A biosystems approach to identify the molecular signaling mechanisms of TMEM30A during tumor migration
Related papers
- The vasohibin family: a novel family for angiogenesis regulation.
- The vasohibin family: Novel regulators of angiogenesis.
- A PlGF-1 Derived Peptide Inhibits Angiogenesis via HIF-1β/VEGF Pathway
- A novel in vitro angiogenesis model based on a microfluidic device
- The Influence of PKA and RhoA on Migration of Gastric Cancer Cells
- Comparison between fibroblast wound healing and cell random migration assays in vitro.
- New method for modeling connective-tissue cell migration: improved accuracy on motility parameters.
- Advances in mechanisms of cancer cell motility and migration