Towards More Effective Antipsychotic Treatment
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Summary
The properties of ‘atypical’ agents challenge the original dopamine hypothesis and suggest roles for a variety of dopamine receptors and for other pathways, such as serotonin.
- Type
- article
- Published
- 1994-11-01
- Cited by
- 58
- References
- 87
- OpenAlex
- https://openalex.org/W83357382
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:731781
Keywords
Antipsychotic, Psychology, Medicine, Schizophrenia (object-oriented programming), Psychiatry
References
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- Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency.
- Akathisia with haloperidol and thiothixene.
- Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia.
- Dimensions of Outcome with Clozapine
- The Effect of Neuroleptics and Other Psychotropic Drugs on Negative Symptoms in Schizophrenia
- Tardive Dyskinesia: A Task Force Report of the American Psychiatric Association
- Treatment programme and long‐term outcome in chronic schizophrenia
- Fluphenazine decanoate, fluphenazine hydrochloride given orally, and placebo in remitted schizophrenics. I. Relapse rates after one year.
- Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
- Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses.
- Developments in the drug treatment of schizophrenia.
- Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics.
- Adverse reaction reporting and new antipsychotics.
- Akathisia: Prevalence and Associated Dysphoria in an In-patient Population with Chronic Schizophrenia
- Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites.
- Treatment of schizophrenia: current practice and future promise.
Cited by
- Risk of osteoporosis and fracture incidence in patients on antipsychotic medication
- Novel Role of the JAK-STAT Pathway in Mediating the Effects of Atypical Antipsychotics on 5-HT2A Receptor Signaling
- Negative symptom and cognitive deficit treatment response in schizophrenia
- The effects of antipsychotics aripiprazole, bifeprunox and haloperidol on body weight regulation and dopamine markers
- Genetics and psychopharmacology: prospects for individualized treatment.
- S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine and haloperidol.
- Placebo-controlled study of the D4/5-HT2A antagonist fananserin in the treatment of schizophrenia.
- Dopamine receptors: from structure to function.
- Risperidone: An assessment of its economic benefits in the treatment of schizophrenia
- Dopamine D2 and D4 receptor ligands: relation to antipsychotic action.
- Clozapine: A Review of its Pharmacological Properties and Therapeutic Use in Patients with Schizophrenia Who Are Unresponsive to or Intolerant of Classical Antipsychotic Agents
- EEG coherence following acute and chronic clozapine in treatment-resistant schizophrenics.
- Presence of D4 dopamine receptors in human prefrontal cortex: a postmortem study.
- Case Histories Illustrating the Utility of Sertindole in Clinical Practice
- Haloperidol- and Clozapine-Induced Enhancement of Latent Inhibition with Extended Conditioning: Implications for the Mechanism of Action of Neuroleptic Drugs
- Individualizing antipsychotic drug therapy in schizophrenia: The promise of pharmacogenetics
- The effects of antipsychotics on β‐catenin, glycogen synthase kinase‐3 and dishevelled in the ventral midbrain of rats
- Quetiapine in patients with schizophrenia. A high- and low-dose double-blind comparison with placebo. Seroquel Study Group.
- Glutamatergic regulation of haloperidol-induced c-fos expression in the rat striatum and nucleus accumbens.
- Induction of c-fos mRNA in rat medial prefrontal cortex by antipsychotic drugs: role of dopamine D2 and D3 receptors.
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