Application of a human bone engineering platform to an in vitro and in vivo breast cancer metastasis model
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Summary
The hypothesis that the translation of a bone tissue engineering platform could lead to improved and more physiological in vitro and in vivo model systems in order to investigate breast cancer related bone colonisation was embraced in this PhD thesis.
- Type
- dissertation
- Published
- 2011-01-01
- Cited by
- 0
- References
- 264
- OpenAlex
- https://openalex.org/W83020937
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:134458942
Keywords
Bone metastasis, Breast cancer, Metastasis, Cancer, In vivo
References
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- Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability.
- Seed and soil revisited: contribution of the organ microenvironment to cancer metastasis.
- Differential Expression of Dentin Matrix Protein 1, Type I Collagen And Osteocalcin Genes in Rat Developing Mandibular Bone
- Osteonectin in matrix remodeling. A plasminogen-osteonectin-collagen complex.
- Increased invasive potential and up-regulation of MMP-2 in MDA-MB-231 breast cancer cells expressing the beta3 integrin subunit.
- The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2.
- Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption.
- E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model.
- The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies
- Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2.
- The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
- Bone sialoprotein peptides are potent inhibitors of breast cancer cell adhesion to bone.
- Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions.
- Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
- Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.
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