[When defense becomes dangerous--transcription factor Nrf2 and cancer].
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Summary
A clear understanding of the role of Nrf2 is essential to assess the beneficial and adverse effects of its up-regulation, particularly in relation to the prevention and treatment of cancer.
- Type
- article
- Published
- 2015-01-23
- Cited by
- 4
- References
- 111
- OpenAlex
- https://openalex.org/W77959829
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31892650
Keywords
Transcription factor, Carcinogenesis, KEAP1, Enzyme, Kinase
References
- Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
- Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*
- Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
- Regulatory Role of KEAP1 and NRF2 in PPARγ Expression and Chemoresistance in Human Non-small Cell Lung Carcinoma Cells
- Involvement of Nrf2 and JNK1 in the Activation of Antioxidant Responsive Element (ARE) by Chemopreventive Agent Phenethyl Isothiocyanate (PEITC)
- Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system
- The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
- Chemoprevention: an essential approach to controlling cancer
- The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.
- Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
- Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
- Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf21
- New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
- Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.
- Isolation of cDNA encoding the human NF-E2 protein.
- Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
- Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.
- Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
- Blocking and suppressing mechanisms of chemoprevention by dietary constituents.
Cited by
- What is responsible for antioxidant properties of polyphenolic compounds from plants?
- Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis
- Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material
- Dietary methanol extract of purslane (Portulaca oleracea L.) can help reduce the negative impacts of triiodothyronine-induced ascites in broiler chickens
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