Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene.
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Summary
The presence of different functional groups in the molecules of stilbenoids influence their antioxidative effect, and modification of these functional groups may result in derivatives with required antioxidative properties, targeting mainly extracellular ROS which are responsible for tissue damage during chronic inflammation.
- Type
- article
- Published
- 2008-10-01
- Cited by
- 62
- References
- 8
- OpenAlex
- https://openalex.org/W68631738
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40214324
Keywords
Pterostilbene, Resveratrol, Chemistry, Extracellular, Intracellular
References
- Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.
- Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production.
- Pharmacometrics of stilbenes: seguing towards the clinic.
- Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity
- Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
- On the pharmacology and toxicology of neutrophils.
- Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine.
Cited by
- Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.
- In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis.
- Caractérisation biochimique et fonctionnelle de glutathion transférases à cystéine catalytique de peuplier (Populus trichocarpa)
- Protective Effects of Pterostilbene against Acetaminophen‐Induced Hepatotoxicity in Rats
- Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs
- On the Molecular Pharmacology of Resveratrol on Oxidative Burst Inhibition in Professional Phagocytes
- The effects of biologically active substances in medicinal plants on the metabolic activity of neutrophils
- Nuclear factor E2-related factor 2-mediated induction of NAD(P)H:quinone oxidoreductase 1 by 3,5-dimethoxy-trans-stilbene.
- Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study.
- Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1 expression in macrophages and inflammatory lung injury
- Phenolic and lipophilic extractives in Pinus merkusii Jungh. et de Vries knots and stemwood
- Ebselen Analogues Reduce 2-chloroethyl Ethyl Sulphide Toxicity in A-431 Cells
- Rational Quantitative Structure-Activity Relationship (RQSAR) Screen for PXR and CAR Isoform-Specific Nuclear Receptor Ligands
- Study of Possible Mechanisms Involved in the Inhibitory Effects of Coumarin Derivatives on Neutrophil Activity
- Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
- The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.
- Effect of stilbene derivative on superoxide generation and enzyme release from human neutrophils in vitro
- Decreased activity and accelerated apoptosis of neutrophils in the presence of natural polyphenols
- Polyphenol derivatives – potential regulators of neutrophil activity
- Immunobiological properties of selected natural and chemically modified phenylpropanoids
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