Altered Integrin Expression and the Malignant Phenotype: The Contribution of Multiple Integrated Integrin Receptors
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Summary
The keyservation is that α2 β1integrin expression is decreased in adenocarcinoma of the breast in a manner that correlates with the stage ofdifferentiation in a way that indicates a critical role forα2β1 expression in mammary gland differentiation.
- Type
- review
- Published
- 1998-04-01
- Cited by
- 53
- References
- 84
- OpenAlex
- https://openalex.org/W61775772
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11147427
Keywords
Integrin, Collagen receptor, Biology, Integrin alpha M, Integrin, beta 6
References
- Integrins: versatility, modulation, and signaling in cell adhesion.
- Low expression of collagen receptors in moderate and poorly differentiated colorectal adenocarcinomas.
- Integrin distributions in renal cell carcinomas of various grades of malignancy.
- Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.
- Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules.
- Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases.
- Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization.
- Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.
- Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
- Alpha 2 beta 1 integrins from different cell types show different binding specificities.
- High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival.
- A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.
- Role of integrins and other cell adhesion molecules in tumor progression and metastasis.
- Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane.
- Cell migration: a physically integrated molecular process.
- Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation.
- The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others.
- Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.
- Basal cell carcinomas display extensive abnormalities in the hemidesmosome anchoring fibril complex
- Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion
Cited by
- Syndecan-1 ectodomain regulates matrix-dependent signaling in human breast carcinoma cells.
- Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition
- Control of Normal Mammary Epithelial Phenotype by Integrins
- The tissue microenvironment as an epigenetic tumor modifier.
- ROLE D'ENDOCAN DANS LA CROISSANCE TUMORALE ET EFFETS DES ANTICORPS ANTI-ENDOCAN SUR LE DEVELOPPEMENT TUMORAL
- The Regulation of Alternative Splicing by Oncogenic Signaling Pathways.
- The Role of Mammary Stroma in Modulating the Proliferative Response to Ovarian Hormones in the Normal Mammary Gland
- Analysis of the Transport Behavior of Escherichia Coli in a Novel Three-Dimensional In Vitro Tumor Model
- The role of systemic metabolism in breast cancer progression
- Diagnostic Implementation of Fast and Selective Integrin-Mediated Adhesion of Cancer Cells on Functionalized Zeolite L Monolayers.
- Role of C/EBPβ in two luminal progenitor populations in the mouse mammary gland
- Estrogen receptor β signalling in mammary epithelial and breast cancer cells
- The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis.
- The Mammary Fat Pad
- Tumor-specific expression of αvβ3 integrin promotes spontaneous metastasis of breast cancer to bone
- Key stages in mammary gland development - The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
- The Tension Mounts: Mechanics Meets Morphogenesis and Malignancy
- Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland
- Population dynamics and clonal dominance in tumors
- Prognostic Significance of αV Integrin and VEGF in Osteosarcoma after Chemotherapy
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