Small GTPases of the Rho family and cell transformation.
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Summary
The Rho GTPases form a distinct subgroup of the Ras superfamily of low molecular weight GTP binding proteins, implicated in signal transduction leading to changes in membrane structures and cytoskeletal reorganisation associated with changes in cell shape.
- Type
- review
- Published
- 1999-01-01
- Cited by
- 18
- References
- 154
- OpenAlex
- https://openalex.org/W61624318
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:634811
Keywords
GTPase, Biology, GTP-binding protein regulators, Ras superfamily, GTP'
References
- A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.
- Role for Ceramide in Cell Cycle Arrest (*)
- A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.
- MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
- 3BP‐1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor‐induced membrane ruffling in fibroblasts.
- Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.
- Tumorigenic activity of rho genes from Aplysia californica.
- rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.
- A novel type of myosin implicated in signalling by rho family GTPases.
- vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
- Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.
- Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.
- Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.
- Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.
- A novel serine kinase activated by rac1/CDC42Hs‐dependent autophosphorylation is related to PAK65 and STE20.
- Identification of a novel Rac1‐interacting protein involved in membrane ruffling.
- Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation (*)
- rac, a novel ras-related family of proteins that are botulinum toxin substrates.
- Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.
- Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae.
Cited by
- TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG.
- p200 RhoGAP Promotes Cell Proliferation by Mediating Cross-talk between Ras and Rho Signaling Pathways*
- Expression of RhoB in the developing Xenopus laevis embryo.
- Rho GTPases and their roles in cancer metabolism
- Farnesylated RhoB Prevents Cell Cycle Arrest and Actin Cytoskeleton Disruption Caused by the Geranylgeranyltransferase I Inhibitor GGTI-298
- Rat lung cancer induced by malathion and estrogen.
- Characterization of TCL, a New GTPase of the Rho Family related to TC10 and Cdc42* 210
- ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway.
- Documentation of Normal and Leukemic Myelopoietic Progenitor Cells with High-Resolution Phase-Contrast Time-Lapse Cinematography
- Dynamic expression patterns of RhoV/Chp and RhoU/Wrch during chicken embryonic development
- Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
- The small GTPase RhoV is an essential regulator of neural crest induction in Xenopus.
- The yeast exchange assay, a new complementary method to screen for Dbl‐like protein specificity: identification of a novel RhoA exchange factor
- Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways.
- Glutaminase: A hot spot for regulation of cancer cell metabolism?
- Extinction of Rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway
- Signalling Networks of Rho GTPases
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