Troponin elevation in heart failure prevalence, mechanisms, and clinical implications.
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Summary
As investigators begin to understand the relationship of detectable cTn to HF outcomes, as well as temporal changes in its magnitude, and its relationship to other circulating biomarkers, more insight may be gained into the progressive nature of cardiac dysfunction and the transition from chronic compensated to acute decompensated HF.
- Type
- review
- Published
- 2010-09-28
- Cited by
- 443
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W49657269
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205538312
Keywords
Medicine, Subclinical infection, Heart failure, Cardiology, Internal medicine
References
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- Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure.
- Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF).
- 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST‐Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update)
- Prognostic Value of Very Low Plasma Concentrations of Troponin T in Patients With Stable Chronic Heart Failure
- Cardiac troponin-I and risk of heart failure: a community-based cohort study.
- Cardiac troponin I: evaluation I of a biomarker for the diagnosis of heart disease in the dog.
- Circulating cardiac troponin I in severe congestive heart failure.
- Cardiac troponin I as prognostic marker in heart failure patients discharged from emergency department
- Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.
- Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure.
- Persistently increased serum concentrations of cardiac troponin in patients with acutely decompensated heart failure are predictive of adverse outcomes.
- Cardiac troponin I as diagnostic and prognostic marker in severe heart failure.
- The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF).
- Identification of Cardiac Troponin I Sequence Motifs Leading to Heart Failure by Inducing Myocardial Inflammation and Fibrosis
- Specificity of a high-sensitivity cardiac troponin I assay using single-molecule-counting technology.
- Cardiac troponins in congestive heart failure.
- Phase III clinical trial end points in acute heart failure syndromes: a virtual roundtable with the Acute Heart Failure Syndromes International Working Group.
- Cardiac Troponin I A Marker With High Specificity for Cardiac Injury
Cited by
- Another piece to the Troponin Puzzle: better confirmed, and with a path forward.
- History of diabetes mellitus is associated with elevated cardiac troponin I levels in patients with chest pain but no coronary heart disease.
- Novel Biomarkers of Heart Failure.
- Galectin-3: a novel blood test for the evaluation and management of patients with heart failure.
- ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevations: a report of the American College of Cardiology Foundation task force on Clinical Expert Consensus Documents.
- The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.
- Rehospitalization for heart failure: problems and perspectives.
- Manejo de la insuficiencia cardiaca aguda en los servicios de urgencias, emergencias y unidades adscritas: documento de consenso del Grupo de Insuficiencia Cardiaca Aguda de la Sociedad Española de Medicina de Urgencias y Emergencias (ICA-SEMES)
- Documento de consenso de expertos. Tercera definición universal del infarto de miocardio
- The Prognostic Value of High-Sensitive Troponin I in Stable Coronary Artery Disease Depends on Age and Other Clinical Variables
- Angiotensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact.
- Características clínicas, terapéuticas y evolutivas de los pacientes con insuficiencia cardiaca aguda atendidos en servicios de urgencias españoles: Registro EAHFE (Epidemiology of Acute Heart Failure in Spanish Emergency Departments)
- High-sensitive cardiac troponin T
- Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes.
- An Investigation of Outcomes in Relation to Thiamin Status of Ambulatory Patients with Heart Failure
- Elevated Troponin Levels in Acute Stroke Patients Predict Long-term Mortality.
- Clinical Interpretation of Elevated Concentrations of Cardiac Troponin T, but Not Troponin I, in Nursing Home Residents.
- High Sensitivity Cardiac Troponins: a Curse or a Blessing?
- Evaluation of remote ischaemic post-conditioning in a pig model of cardiac arrest: A pilot study.
- Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I
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