The sirtuins, oxidative stress and aging: an emerging link
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Summary
Current thinking about the oxidative stress theory of aging is summarized, some of the compelling data linking the sirtuins to ROS and aging are discussed, and a conceptual model placing the sIRTuins into an ROS-driven mitochondria-mediated hormetic response is proposed.
- Type
- review
- Published
- 2013-03-01
- Cited by
- 242
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W47495918
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7781417
Keywords
Calorie restriction, Oxidative stress, Reactive oxygen species, Hormesis, NAD+ kinase
References
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- Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
- Induction of Sirt1 by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response*
- How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis).
- The overexpression of major antioxidant enzymes does not extend the lifespan of mice
- FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2SIRT1*
- Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
- SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
- SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status*♦
- SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
- Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
- Mitochondrial formation of reactive oxygen species
- Toward a unified theory of caloric restriction and longevity regulation.
Cited by
- Clinical Development of Gamitrinib, a Novel Mitochondrial-Targeted Small Molecule Hsp90 Inhibitor
- Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches
- Long noncoding RNAs in Diseases of Aging
- Sirtuins, aging, and cardiovascular risks
- Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss
- Physiology and its importance for reference intervals.
- SIRT5 regulation of ammonia-induced autophagy and mitophagy
- GSK-3 as potential target for therapeutic intervention in cancer
- Genomic integrity and the ageing brain
- Mitochondrial membrane lipidome defines yeast longevity
- Redox Control of Platelet Functions in Physiology and Pathophysiology
- Mitochondrial responsibility in ageing process: innocent, suspect or guilty
- A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance
- Methods for the discovery of new anti-aging products – targeted approaches
- SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort
- Role of Sirtuins in Lifespan Regulation is Linked to Methylation of Nicotinamide
- Growth phase-dependent roles of Sir2 in oxidative stress resistance and chronological lifespan in yeast
- Mitochondrial function and mitochondrial DNA maintenance with advancing age
- FoxO1 at the nexus between fat catabolism and longevity pathways.
- The impact of medium acidity on the chronological life span of Saccharomyces cerevisiae – lipids, signaling cascades, mitochondrial and vacuolar functions
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