Critical assessment of side chain conformation prediction in modelling of single point amino acid mutation.
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Summary
The programs tested seem to produce sufficiently reliable predictions only when mutations involve residues characterized by limited flexibility, which may provide non-experts with insights into what types of modelling protocols work best for such a problem as well as providing information to developers for improving their algorithms.
- Type
- article
- Published
- 2010-01-01
- Cited by
- 3
- References
- 27
- OpenAlex
- https://openalex.org/W45446339
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29610143
Keywords
Side chain, Flexibility (engineering), Point mutation, Computer science, Mutation
References
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- Comparative protein modelling by satisfaction of spatial restraints.
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- Modeling mutations in protein structures
- Advances in homology protein structure modeling.
- Rapid comparison of protein structures
- The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data
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