Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation.
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Summary
It is concluded that alloreactive donor lymphocytes are associated with lung injury in this allogeneic BMT model and their ability to respond to host antigens even when systemic tolerance has been established suggest that the lung may serve as a sanctuary site for these host reactive donor T cells.
- Type
- article
- Published
- 1998-10-01
- Cited by
- 144
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W40112356
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14636560
Keywords
Medicine, Immunology, Graft-versus-host disease, Bone marrow, Minor histocompatibility antigen
References
- Pulmonary dendritic cells: sentinels of lung-associated lymphoid tissues.
- Late CD8+ lymphocytic alveolitis after allogeneic bone marrow transplantation and chronic graft-versus-host disease.
- Bronchiolitis obliterans in bone marrow transplantation and its relationship to chronic graft-v-host disease and low serum IgG.
- Obstructive lung disease in children after allogeneic bone marrow transplantation.
- An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin.
- Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.
- Intermediate TCR cells in mouse lung: their effector function to induce pneumonitis in mice with autoimmune-like graft-versus-host disease.
- Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.
- Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines.
- Potential role of dendritic cells in bronchiolitis obliterans in heart-lung transplantation.
- AN ANALYSIS OF PULMONARY NATURAL KILLER CELL ACTIVITY IN F1‐HYBRID MICE WITH ACUTE GRAFT‐TERSUS-HOST REACTIONS
- A CHRONIC PULMONARY SYNDROME ASSOCIATED WITH GRAFT‐VERSUS-HOST DISEASE AFTER ALLOGENEIC MARROW TRANSPLANTATION
- INTERSTITIAL PNEUMONITIS AND LYMPHOCYTIC BRONCHIOLITIS/BRONCHITIS AS A DIRECT RESULT OF ACUTE LETHAL GRAFT‐VERSUS-HOST DISEASE DUPLICATE THE HISTOPATHOLOGY OF LUNG ALLOGRAFT REJECTION1
- Distribution and immunophenotype of mononuclear phagocytes and dendritic cells in the human lung.
- Clinical course of idiopathic pneumonia after bone marrow transplantation.
- Interstitial pneumonitis after bone marrow transplantation. Assessment of risk factors.
- Overloading the circulation?
- Interstitial pneumonitis after bone-marrow transplantation.
- Airways obstruction associated with graft versus host disease after bone marrow transplantation.
- Proliferative responses of bronchoalveolar lavage lymphocytes from heart-lung transplant patients.
Cited by
- Schädigung respiratorischer Epithelzellen nach allogener Stammzelltransplantation in einem Zellkulturmodell der Graft-versus-Host Reaktion
- Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation.
- Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation.
- Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation
- Role of the cytokine GM-CSF in cell-based anti-tumor immunity: learning from murine models to engineer new therapeutic strategies
- The yin and yang of adaptive immunity in allogeneic hematopoietic cell transplantation: donor antigen-presenting cells can either augment or inhibit donor T cell alloreactivity.
- The chemokine system: a possible therapeutic target in acute graft versus host disease.
- Transgenic Expression of Ly-49A in Thymocytes Alters Repertoire Selection1
- Host Dendritic Cells Alone Are Sufficient to Initiate Acute Graft-versus-Host Disease1
- Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus.
- Donor leukocyte infusion from immunized donors increases tumor vaccine efficacy after allogeneic bone marrow transplantation.
- Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome1
- Conversion of Alloantigen-Specific CD8+ T Cell Anergy to CD8+ T Cell Priming through In Vivo Ligation of Glucocorticoid-Induced TNF Receptor1
- Breaking of CD8+ T Cell Tolerance through In Vivo Ligation of CD40 Results in Inhibition of Chronic Graft-versus-Host Disease and Complete Donor Cell Engraftment1
- The lung as a target organ in patients with hematologic disorders.
- Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation.
- Vigorous inflammatory responses in noninfectious pulmonary complication induced by donor lymphocyte infusion
- Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
- The Role of Chemokines in Mediating Graft Versus Host Disease: Opportunities for Novel Therapeutics
- A revised day +7 predictive score for transplant-related mortality: serum cholinesterase, total protein, blood urea nitrogen, γ glutamyl transferase, donor type and cell dose
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