The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia.
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Summary
Remission was associated with a return to normal serum calcium levels and an improvement of liver function tests, and the use of a monoclonal antibody that blocks the interaction of IL-2 with its receptor expressed on ATL cells provides a rational approach for treatment of this aggressive malignancy.
- Type
- article
- Published
- 1993-09-15
- Cited by
- 131
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W35887377
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28395634
Keywords
Interleukin 2, T-cell leukemia, Leukemia, Monoclonal antibody, Immunology
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Cited by
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- How I treat adult T-cell leukemia/lymphoma.
- Lymphocytes genetically modified to express tumor antigens target dendritic cells in vivo and induce antitumor immunity
- Immunopathogenesis of HIV and HTLV-1 infection: mechanisms for lymphomagenesis.
- Adult T Cell Leukaemia
- Monoclonal Antibodies as Tumour Therapy
- HTLV-I associated leukemia/lymphoma: epidemiology, biology, and treatment.
- The role of interleukin-2 receptor alpha in cancer.
- 同種抹消血幹細胞移植後の再発性皮下腫瘍がcyclosporin A中止により自然消褪した成人T細胞白血病/リンパ腫
- Monoclonal antibody therapy for lymphoma: an update.
- Development of antibodies and chimeric molecules for cancer immunotherapy.
- Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)
- 成人T細胞性白血病／リンパ腫（adult T-cell leukemia/lymphoma; ATLL）と末梢性T細胞リンパ腫-非特定型（Peripheral T-cell lymphoma, not otherwise specified; PTCL-NOS）における免疫組織化学的検討
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- Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD52 monoclonal antibody, Campath-1H.
- Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia.
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