IL-33/ST2L Signaling Provides Neuroprotection Through Inhibiting Autophagy, Endoplasmic Reticulum Stress, and Apoptosis in a Mouse Model of Traumatic Brain Injury
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Summary
It is demonstrated that IL-33/ST2 signaling mitigates TBI-induced brain edema, motor function outcome, spatial learning and memory deficits, at least in part, by a mechanism involving suppressing autophagy, ER stress, apoptosis and neuroinflammation.
- Type
- dissertation
- Published
- 2018-04-25
- Cited by
- 53
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W29922130
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13786433
Keywords
Trout, Geography, Oncorhynchus, Fishery, Ecology
References
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- Production and functions of IL-33 in the central nervous system.
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- Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice.
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- Endoplasmic Reticulum Stress Inhibition Protects against Excitotoxic Neuronal Injury in the Rat Brain
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- Modulation of immune response by head injury.
Cited by
- Serum ST2 as a potential prognostic biomarker for traumatic brain injury.
- The beneficial roles of exercise training via autophagy in neurological diseases and possible mechanisms.
- Salubrinal offers neuroprotection through suppressing endoplasmic reticulum stress, autophagy and apoptosis in a mouse traumatic brain injury model.
- Exosomes from MiR-21-5p-Increased Neurons Play a Role in Neuroprotection by Suppressing Rab11a-Mediated Neuronal Autophagy In Vitro After Traumatic Brain Injury
- IL-33 contributes to disease severity in Psoriasis-like models of mouse.
- Restorative effect of modified dioscorea pills on the structure of hippocampal neurovascular unit in an animal model of chronic cerebral hypoperfusion
- Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria
- The role of Interleukin-33 in the modulation of splenic T-cell immune responses after experimental ischemic stroke.
- Regulation of autophagy in mesenchymal stem cells modulates therapeutic effects on spinal cord injury.
- Soluble ST2, Galectin-3 and clinical prognosis of patients with hypertrophic cardiomyopathy undergoing ventricular septal myectomy: a correlation analysis.
- Targeting endoplasmic reticulum stress and autophagy as therapeutic approaches for neurological diseases.
- Epithelial cells expressed IL-33 to promote degranulation of mast cells through inhibition on ST2/PI3K/mTOR-mediated autophagy in allergic rhinitis
- Extracellular Vesicles miRNA Cargo for Microglia Polarization in Traumatic Brain Injury
- The Function and Mechanisms of Autophagy in Traumatic Brain Injury.
- IL-33 Alleviated Brain Damage via Anti-apoptosis, Endoplasmic Reticulum Stress, and Inflammation After Epilepsy
- TMT-based proteomics analysis to screen potential biomarkers of acute-phase TBI in rats.
- Interleukin‐33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin‐like growth factor‐binding protein 3
- IL-33TRAP-MEDIATED IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model.
- Therapeutic Opportunities of Interleukin-33 in the Central Nervous System
- Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target
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