Molecular Genetics of Frontotemporal Dementia Elucidated by Drosophila Models—Defects in Endosomal–Lysosomal Pathway
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Summary
Current understanding of various FTD-related mutations is discussed with a focus on Drosophila models of CHMP2Bintron5-associated FTD, which encodes a component of endosomal sorting complex required for transport-III (ESCRT-III).
- Type
- article
- Published
- 2018-06-01
- Cited by
- 7
- References
- 100
- Access
- Open access
- OpenAlex
- https://openalex.org/W29890743
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:48363663
Keywords
Computer science
References
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- A Drosophila model for TDP-43 proteinopathy
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- Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
- Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
- Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101.
- Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia
- Structure/Function Analysis of Four Core ESCRT‐III Proteins Reveals Common Regulatory Role for Extreme C‐Terminal Domain
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Cited by
- A Systematic Review of Suggested Molecular Strata, Biomarkers and Their Tissue Sources in ALS
- Modeling Neurodegenerative Disorders in Drosophila melanogaster
- Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
- A novel splice‐site mutation in CHMP2B associated with frontotemporal dementia: The first report from China and literature review
- Exploring the versatility of Drosophila melanogaster as a model organism in biomedical research: a comprehensive review
- Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5
- Useful Flies
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