Physical stability of API/polymer‐blend amorphous solid dispersions
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Summary
The physical stability of API/polymer‐blend ASDs was investigated by thermodynamic modeling and stability studies and PC‐SAFT and the Kwei equation turned out to be suitable tools for modeling and predicting the physical stability.
- Type
- article
- Published
- 2018-03-01
- Cited by
- 69
- References
- 63
- OpenAlex
- https://openalex.org/W29269154
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46786534
Keywords
Baroque, George (robot), Architecture, Art, Art history
References
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- Cellulose based polymers in development of amorphous solid dispersions
- The Influence of Cellulosic Polymer’s Variables on Dissolution/Solubility of Amorphous Felodipine and Crystallization Inhibition from a Supersaturated State
- Broadband dielectric spectroscopy as an experimental alternative to calorimetric determination of the solubility of drugs into polymer matrix: Case of flutamide and various polymeric matrixes
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- Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development
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- Predicting physical stability of solid dispersions by machine learning techniques.
- Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs
- Rivaroxaban polymeric amorphous solid dispersions: moisture-induced thermodynamic phase behavior and intermolecular interactions.
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- Solubility Improvement of Progesterone from Solid Dispersions Prepared by Solvent Evaporation and Co-milling
- The role of molecular interactions on Michaelis constants of α-chymotrypsin catalyzed peptide hydrolyses
- Compression-Induced Phase Transitions of Bicalutamide
- Experimental, thermodynamic and molecular modelling evaluation of amorphous simvastatin-poly(vinylpyrrolidone) solid dispersions.
- Isochronal Conditions—The Key To Maintain the Given Solubility Limit, of a Small Molecule within the Polymer Matrix, at Elevated Pressure
- Physical Stability of Hydroxypropyl Methylcellulose-Based Amorphous Solid Dispersions: Experimental and Computational Study.
- Approaches to understand the solution state organization of spray dried dispersion feed solutions and its translation to the solid state.
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