Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension
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Summary
The activation of A2A receptor could prevent the production of a hypertrophic and dysfunctional phenotype in animal models of cardiovascular diseases, and could potentially serve as a novel and efficient approach for treating PAH and concomitant RV failure.
- Type
- article
- Published
- 2017-12-04
- Cited by
- 34
- References
- 230
- Access
- Open access
- OpenAlex
- https://openalex.org/W29255415
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35354408
Keywords
Focus (optics), Perception, Computer science, Measure (data warehouse), Routing (electronic design automation)
References
- On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins
- Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment.
- Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues.
- Diet and asthma: looking back, moving forward
- Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases
- Adenosine and Adenosine Receptors
- Physiology of the Heart
- Adenosine receptors and diabetes: Focus on the A(2B) adenosine receptor subtype.
- Physiological roles of K+ channels in vascular smooth muscle cells.
- The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium
- Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth.
- Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes
- Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes
- Purification and characterization of intestinal adenosine deaminase from mice
- Signaling Vascular Morphogenesis and Maintenance
- Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline‐induced pulmonary hypertension in rats
- RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.
- Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology
- Adenosine A(2a)-receptor activation increases contractility in isolated perfused hearts.
- Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.
Cited by
- Purinergic Regulation of Neutrophil Function
- Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension
- Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats
- Is the adenosine A2B 'biased' receptor a valuable target for the treatment of pulmonary arterial hypertension?
- Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension.
- Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative
- Comparative study of inorganic, boron-rich cluster and organic, phenyl adenosine modifications: synthesis and properties.
- Vasodepressor Effects of Adenosine in the Cat are Independent of Cyclooxygenase, Potassium Channels, and Nitric Oxide Pathways
- Adenosine and the Cardiovascular System: The Good and the Bad
- Eosinophils and Purinergic Signaling in Health and Disease
- Purinergic Dysfunction in Pulmonary Arterial Hypertension
- Recent Advances in the Role of the Adenosinergic System in Coronary Artery Disease.
- Emerging Mechanisms of Pulmonary Vasoconstriction in SARS-CoV-2-Induced Acute Respiratory Distress Syndrome (ARDS) and Potential Therapeutic Targets
- Co-inhibition of CD73 and ADORA2B Improves Long-Term Cigarette Smoke Induced Lung Injury
- Purinergic Signaling in Controlling Macrophage and T Cell Functions During Atherosclerosis Development
- Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists
- Novel and emerging therapies in pulmonary arterial hypertension
- Safety Assessment of Adenosine as Used in Cosmetics
- Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension
- Modulatory effect of ethylacetate fraction from Theobroma cacao pod husk on blood pressure in L-NAME-induced hypertensive rats using in vivo and in silico approaches
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