Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity
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Summary
This model suggests that the presence of GC dendrites is associated with high pattern separation efficiency while their atrophy leads to increased excitability and performance impairments, which can be rescued by restoring GC sparsity to control levels through various manipulations.
- Type
- article
- Published
- 2016-11-10
- Cited by
- 72
- References
- 91
- Access
- Open access
- OpenAlex
- https://openalex.org/W27784124
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17842475
Keywords
Sociology, Public relations, Political science, Epistemology, Philosophy
References
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Cited by
- In vivo imaging of dentate gyrus mossy cells in behaving mice
- Pattern separation in the hippocampus through the eyes of computational modeling
- Exposure to complex environments results in more sparse representations of space in the hippocampus
- Activity-dependent expression of Channelrhodopsin at neuronal synapses
- 26th Annual Computational Neuroscience Meeting (CNS*2017): Part 1
- Integrating new findings and examining clinical applications of pattern separation
- Contributions of Adult-Generated Granule Cells to Hippocampal Pathology in Temporal Lobe Epilepsy: A Neuronal Bestiary
- Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks
- Temporal pattern separation in hippocampal neurons through multiplexed neural codes
- Disparate forms of heterogeneities and interactions among them drive channel decorrelation in the dentate gyrus: Degeneracy and dominance
- Re-evaluating circuit mechanisms underlying pattern separation
- Pattern separation of spiketrains in hippocampal neurons
- Functions of adult-born neurons in hippocampal memory interference and indexing
- A general principle of dendritic constancy – a neuron’s size and shape invariant excitability
- Quantitative properties of a feedback circuit predict frequency-dependent pattern separation
- Hippocampal pattern separation of emotional information determining risk or resilience in individuals exposed to childhood trauma: linking exposure to neurodevelopmental alterations and threat anticipation.
- Adult neurogenesis and the dentate gyrus: predicting function from form.
- Modeling of Brain-Like Concept Coding with Adulthood Neurogenesis in the Dentate Gyrus
- An Investigation into the Effective Role of Astrocyte in the Hippocampus Pattern Separation Process: A Computational Modeling Study.
- The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis
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