Hepatitis B virus dampens autophagy maturation via negative regulation of Rab7 expression.
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Summary
A potential mechanism for how HBV escapes autophagic degradation is proposed, which might be a novel therapeutic target for controlling HBV infection.
- Type
- article
- Published
- 2016-07-11
- Cited by
- 44
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W27396843
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23252071
Keywords
Hegelianism, Philosophy, Epistemology
References
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- PLEKHM1: a multiprotein adaptor for the endolysosomal system.
- Regulation of Hepatitis B Virus Replication by the Ras-Mitogen-Activated Protein Kinase Signaling Pathway
- Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation
- Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.
- Viruses and autophagy
- Autophagy in Health and Disease: A Double-Edged Sword
- HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation
- Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination
- Thapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagy
- Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll‐like receptor‐mediated autophagy
- Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice
- Rab7: roles in membrane trafficking and disease.
- Autophagy and Burkholderia
Cited by
- Protein Interactions in the Last Steps of the Endosomal Degradative Pathway
- Vorinostat and Simvastatin have synergistic effects on triple‐negative breast cancer cells via abrogating Rab7 prenylation
- Membrane Trafficking in Autophagy.
- X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy
- Autophagy in the "inflammation-carcinogenesis" pathway of liver and HCC immunotherapy.
- Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis
- The role of HBV‐induced autophagy in HBV replication and HBV related‐HCC
- HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: Role of BCP and preCore mutations
- Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway
- Human Papilloma Virus and Autophagy
- Mechanisms of the autophagosome-lysosome fusion step and its relation to non-alcoholic fatty liver disease
- Host Cell Rab GTPases in Hepatitis B Virus Infection
- Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway
- N‐myc and STAT interactor correlates with severity and prognosis in acute‐on‐chronic liver failure of hepatitis B virus
- Synaptosomal‐associated protein 29 is required for the autophagic degradation of hepatitis B virus
- Hepatitis B virus X protein enhances the development of liver fibrosis and the expression of genes associated with epithelial-mesenchymal transitions and tumor progenitor cells.
- Harmonized Autophagy Versus Full-Fledged Hepatitis B Virus: Victorious or Defeated
- Autophagy in hepatitis B or C virus infection: An incubator and a potential therapeutic target.
- Regulation of Autophagy in Cells Infected With Oncogenic Human Viruses and Its Impact on Cancer Development
- SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
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