HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment
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Summary
The functional roles of Met and HGF in HNSCC are discussed with a focus on the tumor microenvironment and the immune system.
- Type
- article
- Published
- 2016-07-01
- Cited by
- 91
- References
- 93
- OpenAlex
- https://openalex.org/W27370607
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8603683
Keywords
Computer science
References
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- Crizotinib in ROS1-rearranged non-small-cell lung cancer.
- Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis.
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- Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.
- Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy.
- A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
- Crizotinib Fails to Enhance the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Xenografts.
- MET is required for the recruitment of anti-tumoural neutrophils
- Expression profile and in vitro blockade of programmed death-1 in human papillomavirus–negative head and neck squamous cell carcinoma
- Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
- Dendritic cells hold promise for immunotherapy.
- Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40‐ligand) and TNF‐α, but strongly enhanced by interleukin‐10
- Comprehensive genomic characterization of head and neck squamous cell carcinomas
- Head neck squamous cell carcinoma c‐Met+ cells display cancer stem cell properties and are responsible for cisplatin‐resistance and metastasis
- Head and neck cancer: changing epidemiology, diagnosis, and treatment.
- Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.
- Involvement of the hepatocyte growth factor/scatter factor receptor c–met and of Bcl–xL in the resistance of oropharyngeal cancer to ionizing radiation
- The tumor microenvironment is a dominant force in multidrug resistance
Cited by
- Myeloid‐derived suppressor cells and tumor: Current knowledge and future perspectives
- Alteration status and prognostic value of MET in head and neck squamous cell carcinoma
- Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment
- Novel Treatment Options in Head and Neck Cancer
- Identification of a novel population of highly cytotoxic c‐Met‐expressing CD8+ T lymphocytes
- Detection of TGF-β1, HGF, IGF-1 and IGF-1R in Cleft Affected Mucosa of the Lip
- Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
- Efficacy and safety of anti‐EGFR agents administered concurrently with standard therapies for patients with head and neck squamous cell carcinoma: a systematic review and meta‐analysis of randomized controlled trials
- Tumor microenvironment - Unknown niche with powerful therapeutic potential.
- The role of tumor microenvironment in resistance to anti-angiogenic therapy
- Interaction between human osteosarcoma and mesenchymal stem cells via an interleukin-8 signaling loop in the tumor microenvironment
- A phase I study of LY3164530, a bispecific antibody targeting MET and EGFR, in patients with advanced or metastatic cancer
- Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma
- Characterisation of cytokine secretion in malignant gliomas
- HGF/c-MET Signaling in Melanocytes and Melanoma
- Receptor tyrosine kinase MET as potential target of multi‐kinase inhibitor and radiosensitizer sorafenib in HNSCC
- IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway
- Desmoglein 1 regulates invadopodia by suppressing EGFR/Erk signaling in an Erbin-dependent manner
- MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer
- Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer
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