Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation.
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Summary
The role of epigenetics in downregulation of host macrophages by Leishmania that could potentially lead to a permanent state of inactivation, thus favoring pathogen survival and disease progression is examined.
- Type
- review
- Published
- 2016-07-01
- Cited by
- 51
- References
- 46
- OpenAlex
- https://openalex.org/W2344371263
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3671054
Keywords
Epigenetics, Intracellular parasite, Biology, Intracellular, Leishmania
References
- Advances in leishmaniasis.
- Pathogens hijack the epigenome: a new twist on host-pathogen interactions.
- Leishmania survival in the macrophage: where the ends justify the means.
- Toxoplasma gondii Prevents Chromatin Remodeling Initiated by TLR-Triggered Macrophage Activation
- Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections
- Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages
- A Vectorial Capacity Product to Monitor Changing Malaria Transmission Potential in Epidemic Regions of Africa
- Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging
- Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala
- Epigenetics of Host–Pathogen Interactions: The Road Ahead and the Road Behind
- Leishmania promastigotes: building a safe niche within macrophages
- Host Cell Signalling and Leishmania Mechanisms of Evasion
- Leishmaniasis: complexity at the host–pathogen interface
- Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure
- Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.
- Impact of Leishmania Infection on Host Macrophage Nuclear Physiology and Nucleopore Complex Integrity
- Epigenetic reprogramming of host genes in viral and microbial pathogenesis
- Apicomplexan parasites and subversion of the host cell microRNA pathway.
- An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages
- Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.
Cited by
- Histone deacetylase inhibitor MS-275 augments expression of a subset of IFN-γ-regulated genes in Toxoplasma gondii-infected macrophages but does not improve parasite control.
- Medicinal plant products targeting quorum sensing for combating bacterial infections.
- Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation
- Etude biochimique, biophysique et structurale du mécanisme d'action et de l'inhibition sélective de l'histone désacétylase HDAC8
- Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes
- Toward an integrative molecular approach to wildlife disease
- CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms
- Leishmania amazonensis downregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism
- Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni
- GZMA and RASGRP1 are novel tumor suppressors that counter dissemination of Theileria annulata-transformed macrophages
- Genome‐wide DNA methylation signatures of infection status in Trinidadian guppies (Poecilia reticulata)
- Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses
- Disrupting the Code: Epigenetic Dysregulation of Lymphocyte Function during Infectious Disease and Lymphoma Development
- The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases
- Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle
- Experimental infection of Friesian bulls with Theileria orientalis (Ikeda) and effects on the haematocrit, live weight, rectal temperature and activity.
- A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility
- Age-Related Changes on CD40 Promotor Methylation and Immune Gene Expressions in Thymus of Chicken
- Epigenetic regulation of the innate immune response to infection
- Behavioural, convergent and ontogenetic evidence for adaptive behavioural manipulation in mermithid infected hosts
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