Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats.
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Summary
Both apigenin and naringenin can ameliorate glucose and lipid metabolism, as well as endothelial dysfunction in T2D rats at least in part by down-regulating oxidative stress and inflammation.
- Type
- article
- Published
- 2016-02-15
- Cited by
- 200
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W26801071
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26958611
Keywords
Connectionism, Aphasia, Cognition, Psychology, Computer science
References
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- Spasmolytic effects of Baccharis conferta and some of its constituents
- Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation.
- Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats.
- Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner.
- Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin.
- Homoplantaginin modulates insulin sensitivity in endothelial cells by inhibiting inflammation.
- Can type 2 diabetes mellitus be considered preventable?
- Cochlospermum vitifolium induces vasorelaxant and antihypertensive effects mainly by activation of NO/cGMP signaling pathway.
- Studies on lipid peroxidation in the rat brain
- Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats
- Antihyperglycaemic and protective effects of flavonoids on streptozotocin–induced diabetic rats
- Inhibitory effects of quercetin and other flavonoids on electrically-induced contractions of guinea pig isolated ileum.
- The mechanism of vasorelaxation induced by ethanol extract of Sophora flavescens in rat aorta.
Cited by
- The significant impact of apigenin on different aspects of autoimmune disease
- Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose.
- Hypoglycemic effect of Chrysanthemum morifolium extract on alloxan-induced diabetic mice is associated with peroxisome proliferator-activated receptor α/γ-mediated hepatic glycogen synthesis
- Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector
- Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp.
- Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense
- Chrysin and baicalin in diabetic nephropathy.
- An insight into anti-diabetic properties of dietary phytochemicals
- Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights.
- Apigenin: A current review on its beneficial biological activities
- Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways.
- Development of an ultra-fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of seven flavonoids in rat plasma: Application to a comparative pharmacokinetic investigation of Ginkgo biloba extract and single pure ginkgo flavonoids after oral administration.
- A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation
- Involvement of Smad3 pathway in atrial fibrosis induced by elevated hydrostatic pressure
- Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms
- Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases
- Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi.
- A review on the structure–activity relationship of dietary flavonoids for protecting vascular endothelial function: Current understanding and future issues
- Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner.
- Dietary flavonoids as a potential intervention to improve redox balance in obesity and related co-morbidities: a review
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