A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.
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Summary
This pharmacoepigenomic regulatory pathway is located in the same brain regions that exhibit tissue volume loss in bipolar disorder and provides value for identification of candidate variants that may be used in pharmacogenomic testing to identify bipolar patients likely to respond to lithium.
- Type
- article
- Published
- 2015-09-07
- Cited by
- 41
- References
- 141
- OpenAlex
- https://openalex.org/W26343379
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22594326
Keywords
Chemistry
References
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Cited by
- The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics.
- Can a systems approach produce a better understanding of mood disorders?
- Therapeutic Mechanisms of Lithium in Bipolar Disorder: Recent Advances and Current Understanding
- DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling
- Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry
- Lithium response in bipolar disorders and core clock genes expression
- The gender-specific association of rs334558 in GSK3β with major depressive disorder
- Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways.
- Biological treatment of Acute Agitation Or Aggression with Schizophrenia Or Bipolar Disorder in the Inpatient Setting
- Biological effects of lithium – fundamental and medical aspects
- High genetic loading of schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis
- Revisión sistemática de la evidencia de existencia de marcadores genéticos en la respuesta al litio en pacientes con trastorno bipolar tipo i
- Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study
- An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms
- Recent trends on the role of epigenomics, metabolomics and noncoding RNAs in rationalizing mood stabilizing treatment.
- Deep Learning in Pharmacogenomics: From Gene Regulation to Patient Stratification
- The pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants.
- Pharmacogenetics in Psychiatry.
- The Role of Pharmacogenomics in Bipolar Disorder: Moving Towards Precision Medicine
- Neurology in the Light of Genomics: Application of NGS and GWAS in Understanding Complex Neurological Disorders
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