The state-of-play and future of platinum drugs.
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Summary
Functional genomics is now playing an increasing role in predicting patients' responses to platin chemotherapy and their likelihood of experiencing severe side effects, reflecting a shift in research focus from new drug design to improved formulations of already approved platin drugs.
- Type
- article
- Published
- 2015-08-01
- Cited by
- 218
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W26113607
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7192373
Keywords
Work (physics), Environmental education, Environmental adult education, Environmental planning, Political science
References
- Common Variants in ACYP2 Influence Susceptibility to Cisplatin-induced Hearing Loss
- TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer.
- The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators.
- Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles.
- Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect.
- A double-blind, randomized phase II study of dicycloplatin plus paclitaxel versus carboplatin plus paclitaxel as first-line therapy for patients with advanced non-small-cell lung cancers
- A synthetic peptide mediated active targeting of cisplatin liposomes to Tie2 expressing cells.
- Dendrimers and nanomedicine: multivalency in action
- Platinum(II) as Bifunctional Linker in Antibody–Drug Conjugate Formation: Coupling of a 4‐Nitrobenzo‐2‐oxa‐1,3‐diazole Fluorophore to Trastuzumab as a Model
- Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies.
- The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.
- Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes
- Metal-based antitumour drugs in the post genomic era.
- Integrin-targeted delivery into cancer cells of a Pt(IV) pro-drug through conjugation to RGD-containing peptides.
- Tumor delivery of macromolecular drugs based on the EPR effect.
- Cucurbituril binding of trans-[PtCl(NH3)22(micro-NH2(CH2)8NH2)]2+ and the effect on the reaction with cysteine.
- Cisplatin in cancer therapy: molecular mechanisms of action
- Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles.
- In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes.
- Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval?
Cited by
- Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction.
- Complexation of cis-Pt and trans-Pt(NH3)2Cl2 with serum proteins: A potential application for drug delivery
- Exploiting developments in nanotechnology for the preferential delivery of platinum-based anti-cancer agents to tumours: targeting some of the hallmarks of cancer.
- Toward CO-based Therapeutics: Critical Drug Delivery and Developability Issues
- Platinum-based drugs: past, present and future
- Role of Biomarkers in the Development of PARP Inhibitors
- Characterization of thioredoxin related protein of 14 kDa and its role in redox signaling
- Platinum-based chemotherapy in advanced non-small-cell lung cancer: optimal number of treatment cycles
- Multifunctional platinum-based nanoparticles for biomedical applications.
- Effects of NVP-BEZ235 on the proliferation, migration, apoptosis and autophagy in HT-29 human colorectal adenocarcinoma cells.
- Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin
- Platinum-based anticancer drugs encapsulated liposome and polymeric micelle formulation in clinical trials
- Chemophototherapy: An Emerging Treatment Option for Solid Tumors
- Anticancer activity of a chelating nitrogen mustard bearing tetrachloridoplatinum(iv) complex: better stability yet equipotent to the Pt(ii) analogue.
- Time-programmed DCA and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery.
- Therapeutic potential and critical analysis of trastuzumab and bevacizumab in combination with different chemotherapeutic agents against metastatic breast/colorectal cancer affecting various endpoints.
- Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.
- Exploring saccharinate-tetrazoles as selective Cu(II) ligands: structure, magnetic properties and cytotoxicity of copper(II) complexes based on 5-(3-aminosaccharyl)-tetrazoles
- The significance of c.690G>T polymorphism (rs34529039) and expression of the CEBPA gene in ovarian cancer outcome
- Self‐Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity
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