Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis
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Summary
Evidence is provided of a novel role for Gal-3 in regulating IL-33-dependent liver fibrosis in HFD-fed mice in both genotypes, albeit to a significantly lower extent in LGALS3−/− mice, which was associated with less numerous hepatic IL-13-expressing CD11b+ cells.
- Type
- article
- Published
- 2015-05-22
- Cited by
- 85
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W26018806
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10267520
Keywords
Political science, Economics
References
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Cited by
- IL-33 Prevents MLD-STZ Induction of Diabetes and Attenuate Insulitis in Prediabetic NOD Mice
- Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
- Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages.
- IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis
- n-3 Fatty acids modulate the mRNA expression of the Nlrp3 inflammasome and Mtor in the liver of rats fed with high-fat or high-fat/fructose diets
- The Two Faces of Galectin-3: Roles in Various Pathological Conditions
- Randomised clinical study: GR‐MD‐02, a galectin‐3 inhibitor, vs. placebo in patients having non‐alcoholic steatohepatitis with advanced fibrosis
- Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis
- The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications
- A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis.
- Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease
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- Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis
- NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
- IL-33/ST2 Axis in Organ Fibrosis
- Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection
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