The TGFβ Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone
Explore this paper's citation graph
Summary
This study reveals that the TGFBR1 inhibitor SD208 effectively reduces prostate cancer bone metastases and PMEPA1 expression, and interrupts this negative feedback loop by PMEPA1 knockdown increased prometastatic gene expression and bone metastases in a mouse prostate cancer model.
- Type
- article
- Published
- 2015-05-14
- Cited by
- 203
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W25982816
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41178086
Keywords
Continuing education, Continuing professional development, Professional development, Service (business), Medical education
References
- Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
- An MMP13-Selective Inhibitor Delays Primary Tumor Growth and the Onset of Tumor-Associated Osteolytic Lesions in Experimental Models of Breast Cancer
- Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.
- Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models.
- An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.
- NEDD9 crucially regulates TGF‐β‐triggered epithelial–mesenchymal transition and cell invasion in prostate cancer cells: Involvement in cancer progressiveness
- A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells*
- Gene expression profiling of the tumor microenvironment during breast cancer progression
- Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
- Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.
- Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer
- Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone
- Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.
- Novel Pathways Associated with Bypassing Cellular Senescence in Human Prostate Epithelial Cells* 210
- Urokinase-type plasminogen activator.
- Inhibitor of differentiation 1 (Id1) promotes cell survival and proliferation of prostate epithelial cells
- A multigenic program mediating breast cancer metastasis to bone.
- AIP4 Restricts Transforming Growth Factor-β Signaling through a Ubiquitination-independent Mechanism*
- Diversity of gene expression in adenocarcinoma of the lung
- Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis*
Cited by
- TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity.
- The origin of prostate metastases: emerging insights
- CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer
- Surviving at a distance: organ specific metastasis
- Functional screen identifies kinases driving prostate cancer visceral and bone metastasis
- Molecular Mechanisms of Bone Metastasis.
- Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
- The impact of bone morphogenetic protein 4 (BMP4) on breast cancer metastasis in a mouse xenograft model.
- A novel model used to detect differential splice junctions as biomarkers in prostate cancer from RNA-Seq data
- Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer
- TMEPAI increases lysosome stability and promotes autophagy.
- Bone metastasis: the importance of the neighbourhood
- Genomic characterization of liver metastases from colorectal cancer patients
- Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer
- Determinants of Organotropic Metastasis
- Transforming growth factor β as regulator of cancer stemness and metastasis
- PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors.
- Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone
- Inhibition of KPNA4 Attenuates Prostate Cancer Metastasis
- Clinicopathological study of 9 cases of prostate cancer involving the rectal wall
Related papers
No related papers recorded.