The TGFβ Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone

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Summary

This study reveals that the TGFBR1 inhibitor SD208 effectively reduces prostate cancer bone metastases and PMEPA1 expression, and interrupts this negative feedback loop by PMEPA1 knockdown increased prometastatic gene expression and bone metastases in a mouse prostate cancer model.

Type
article
Published
2015-05-14
Cited by
203
References
54
Access
Open access

Keywords

Continuing education, Continuing professional development, Professional development, Service (business), Medical education

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