The Mechanism of Melanocytes-Specific Cytotoxicity Induced by Phenol Compounds Having a Prooxidant Effect, relating to the Appearance of Leukoderma
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Summary
Hydroxyl radical was generated by adding a mixture of tyrosinase and H2O2 to RD, and the amount of the radical was further increased by UVB, indicating that RD cytotoxicity was caused by intracellularly increased ROS, which possibly related to phenol induced prooxidants.
- Type
- article
- Published
- 2015-03-12
- Cited by
- 24
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W25861631
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10264822
Keywords
Inconel, Metallurgy, Materials science
References
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- Tyrosinase‐catalyzed oxidation of rhododendrol produces 2‐methylchromane‐6,7‐dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity
Cited by
- Biochemical Mechanism of Rhododendrol-Induced Leukoderma
- Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes
- Rhododenol and raspberry ketone impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45.
- DESIGN OF HYDROQUINONE INDICATOR STRIP BASED ON POLYMETHYLMETHACRYLATE (PMMA) FOR IDENTIFICATION OF HYDROQUINONE IN WHITENING COSMETICS: CASE STUDY IN BANDUNG INDONESIA
- Generation of hydroxyl radicals and singlet oxygen during oxidation of rhododendrol and rhododendrol-catechol
- Investigation of Phenols Activity in Early Stage Oxidation of Edible Oils by Electron Paramagnetic Resonance and 19F NMR Spectroscopies Using Novel Lipid Vanadium Complexes As Radical Initiators.
- Reduced Nrf2 activation in PI3K phosphorylation‐impaired vitiliginous keratinocytes increases susceptibility to ROS‐generating chemical‐induced apoptosis
- The potent pro‐oxidant activity of rhododendrol–eumelanin is enhanced by ultraviolet A radiation
- Endogenous lycopene improves ethanol production under acetic acid stress in Saccharomyces cerevisiae
- 4‐(4‐Hydroxyphenyl)‐2‐butanol (rhododendrol)‐induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress
- 3-O-Glyceryl-2-O-hexyl Ascorbate Suppresses Melanogenesis through Activation of the Autophagy System.
- Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma.
- Relevance of functional foods in the Mediterranean diet: the role of olive oil, berries and honey in the prevention of cancer and cardiovascular diseases
- Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity
- HPTLC fingerprinting analysis and in vitro pharmacological activities of Hermannia geniculata roots phenols
- Rhododendrol‐induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism‐based treatments in comparison with vitiligo
- Chemical profiling, in vitro antioxidant and antidiabetic assessment of flavonoids from the ethanol extract of Hermannia geniculata root
- Zebrafish as a new model for rhododendrol‐induced leukoderma
- The Multi-Berry Extracts Improved Aging Skin and Increased Antioxidant Capacity
- Melanocytotoxic chemicals and their toxic mechanisms
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