Antiviral Drug- and Multidrug Resistance in Cytomegalovirus Infected SCT Patients
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Summary
In pediatric and adult patients after stem cell transplantation (SCT) disseminated infections caused by human cytomegalovirus (HCMV) can cause life threatening diseases, and resistance to all of these antiviral drugs may induce a severe problem in this patient cohort.
- Type
- dissertation
- Published
- 2015-02-10
- Cited by
- 48
- References
- 94
- Access
- Open access
- OpenAlex
- https://openalex.org/W25750703
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1947687
Keywords
Humanities, Philosophy, Mathematics, Physics
References
- Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome.
- Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes.
- Worldwide Evaluation of DNA Sequencing Approaches for Identification of Drug Resistance Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
- A simplified assay for screening of drug resistance of cell-associated cytomegalovirus strains.
- The Cys607→Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients
- A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate
- CMV: Prevention, Diagnosis and Therapy
- En passant mutagenesis: a two step markerless red recombination system.
- Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS
- Efficacy and Safety of Maribavir Dosed at 100 mg Orally Twice Daily for the Prevention of Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized, Double‐Blind, Multicenter Controlled Trial
- Drug targets in cytomegalovirus infection.
- Rapid Simultaneous Detection by Real-Time PCR of Cytomegalovirus UL97 Mutations in Codons 460 and 520 Conferring Ganciclovir Resistance
- Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model.
- How we treat cytomegalovirus in hematopoietic cell transplant recipients.
- Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant.
- Multidrug Resistance Conferred by Novel DNA Polymerase Mutations in Human Cytomegalovirus Isolates
- Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain.
- Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs.
- Antiviral resistance in cytomegalovirus: an emerging problem in organ transplant recipients.
- Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli.
Cited by
- Patients with refractory cytomegalovirus (CMV) infection following allogeneic haematopoietic stem cell transplantation are at high risk for CMV disease and non-relapse mortality.
- Sequencing drug-resistant cytomegalovirus in pediatric patients: toward personalized medicine
- Clinical manifestations of meningoencephalitis in HIV-positive patients depending on the etiological factor meningoencephalitis
- Persistent CMV infection after allogeneic hematopoietic stem cell transplantation in a CMV-seronegative donor-to-positive recipient constellation: Development of multidrug resistance in the absence of anti-viral cellular immunity.
- Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art
- Characterization of cytomegalovirus resistant strains in hematopoietic stem cell transplanted patients
- Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation
- Rapid emergence of HCMV drug resistance in immunocompromised paediatric patients detected using target enrichment and deep sequencing
- [Investigation of ganciclovir resistance in CMV UL54 and UL97 gene regions in immunocompromised patients receiving gancyclovir treatment].
- Progress in Treatment of Viral Infections in Children with Acute Lymphoblastic Leukemia
- Detection of Low Frequency Multi-Drug Resistance and Novel Putative Maribavir Resistance in Immunocompromised Pediatric Patients with Cytomegalovirus
- Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase
- Genotypic resistance of cytomegalovirus to antivirals in hematopoietic stem cell transplant recipients from Portugal: A retrospective study
- Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes
- Frequent pUL27 Variations in HIV-Infected Patients
- Identification of Human Cytomegalovirus pUL27 R233 point mutation using PCR-RFLP
- Human cytomegalovirus UL54 and UL97 mutations for detection of ganciclovir resistance in congenital infection
- Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.
- Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer's Disease - A Review.
- Characterization of phenyl pyrimidine derivatives that inhibit cytomegalovirus immediate-early gene expression
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