Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis
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Summary
It is shown that unlike its untargeted counterpart α-tocopheryl succinate, MitoVES suppresses proliferation of cancer cells at sub-apoptotic doses by way of affecting the mitochondrial DNA (mtDNA) transcripts.
- Type
- article
- Published
- 2015-03-31
- Cited by
- 46
- References
- 69
- OpenAlex
- https://openalex.org/W25578105
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2819567
Keywords
Anthocyanidins, Oxidative stress, Oxidative phosphorylation, Chemistry, Biochemistry
References
- A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression.
- Inhibition of angiogenesis and vascular tumor growth by interferon-producing cells: A gene therapy approach.
- The D-loop structure of human mtDNA is destabilized directly by 1-methyl-4-phenylpyridinium ion (MPP+), a parkinsonism-causing toxin.
- Phosphatidylinositol 3‐kinase affects mitochondrial function in part through inducing peroxisome proliferator‐activated receptor γ coactivator‐1β expression
- Epicatechin in Human Plasma: In Vivo Determination and Effect of Chocolate Consumption on Plasma Oxidation Status
- Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II
- Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
- Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.
- Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling.
- α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
- Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria
- Evolutionary tinkering with mitochondrial nucleoids.
- DNA polymerase γ inhibition by vitamin K3 induces mitochondria‐mediated cytotoxicity in human cancer cells
- Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II*
- Fine‐tuning the hydrophobicity of a mitochondria‐targeted antioxidant
- Relationships between the effects of redox potential, α‐Thenoyltrifluoroacetone and malonate on O2 − and H2O2 generation by submitochondrial particles in the presence of succinate and antimycin
- Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells.
- Mammalian transcription factor A is a core component of the mitochondrial transcription machinery
Cited by
- Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives
- Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
- Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents
- Using imidazolium-based ionic liquids as dual solvent-catalysts for sustainable synthesis of vitamin esters: inspiration from bio- and organo-catalysis
- Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation
- Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy.
- Cellular energetics as a target for tumor cell elimination
- Breast Cancer Stem Cells & Therapy Resistance
- Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer
- Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
- Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
- Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.
- Tocotrienols: the unsaturated sidekick shifting new paradigms in vitamin E therapeutics.
- Mitochondrial Biogenesis in Response to Chromium (VI) Toxicity in Human Liver Cells
- Mitochondrial dynamics in the radiation response of cancer cells
- Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
- 4-Imidazol-1-yl-butane-1-sulfonic acid ionic liquid: Synthesis, structural analysis, physical properties and catalytic application as dual solvent-catalyst
- Physalin B induces G2/M cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by altering mitochondrial function
- Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
- Potential therapy strategy: targeting mitochondrial dysfunction in sepsis
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