Virion-Independent Transfer of Replication-Competent Hepatitis C Virus RNA between Permissive Cells
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Summary
It is shown that replication-competent subgenomic hepatitis C virus RNA can be transferred to permissive Huh7 cells, leading to the establishment of viral RNA replication, mediated by exosomes rather than infectious virus particles.
- Type
- article
- Published
- 2014-12-10
- Cited by
- 113
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W1968418254
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27010684
Keywords
Biology, Subgenomic mRNA, Virology, Permissive, Viral replication
References
- Exosome‐release of beta‐catenin: A novel mechanism to antagonize Wnt signaling
- Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
- Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon.
- Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses
- Hepatitis C virus: Buoyant density if the factor VIII‐derived isolate in sucrose
- Inter-cellular nanovesicle mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth
- Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains
- Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells
- Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90
- Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
- Robust hepatitis C virus infection in vitro.
- Plasmacytoid dendritic cells sense hepatitis C virus–infected cells, produce interferon, and inhibit infection
- Short range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity
- Hepatitis C virus particles of different density in the blood of chronically infected immunocompetent and immunodeficient patients: Implications for virus clearance by antibody
- Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
- Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture
- Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells*♦
- Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
- Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion
- Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs*
Cited by
- Investigating the modulation of viral translation by the Hepatitis C virus nonstructural protein 5A
- Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses
- Regulation of the Host Antiviral State by Intercellular Communications
- Intercellular Transmission of Viral Populations with Vesicles
- Extracellular vesicles from infected cells: potential for direct pathogenesis
- The Dual Role of Exosomes in Hepatitis A and C Virus Transmission and Viral Immune Activation
- Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway
- Recent advances in understanding hepatitis C
- Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles
- Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma
- Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery
- Biological roles of cellular glyceraldehyde-3-phosphate dehydrogenase in the hepatitis C virus life cycle
- Extracellular vesicles are the Trojan horses of viral infection
- Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway.
- Exosomes in Viral Disease
- Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner
- Immunomodulatory effects of exosomes produced by virus-infected cells.
- Exosomes: From Functions in Host-Pathogen Interactions and Immunity to Diagnostic and Therapeutic Opportunities.
- Emerging role of exosomes in liver physiology and pathology
- Reviews of Physiology, Biochemistry and Pharmacology, Vol. 172
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