Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.
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Summary
The results demonstrate the feasibility of detection of subclinical inflammatory disease activity in vivo, which is different from overt BBB breakdown, and specifically reveals lesions with inflammatory monocytes and neutrophils, which actively secrete MPO.
- Type
- book
- Published
- 2015-05-01
- Cited by
- 38
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W25494298
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37488429
Keywords
Middle class, Everyday life, Ambiguity, Taste, Ethnography
References
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- MRI‐based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE
- Epidemiology of Multiple Sclerosis: A Critical Overview
- Treatment with anti-granulocyte antibodies inhibits the effector phase of experimental autoimmune encephalomyelitis.
- Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes.
- Isolation of brain and spinal cord mononuclear cells using percoll gradients.
- A paramagnetic contrast agent with myeloperoxidase-sensing properties.
- Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with Gadofluorine M.
- Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis.
- Myeloperoxidase attracts neutrophils by physical forces.
- Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
- Mini‐review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
- Macrophages in T cell line‐mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats
- Contributions of Myeloperoxidase to Proinflammatory Events: More Than an Antimicrobial System
- Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
- White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis
- The blood-brain barrier and the inflammatory response.
- Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities
- The clinico‐radiological paradox in multiple sclerosis revisited
- Cortical demyelination and diffuse white matter injury in multiple sclerosis.
Cited by
- Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice
- Science to practice: myeloperoxidase immunoradiology improves detection of acute and chronic experimental multiple sclerosis.
- Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis
- Inhibition of Myeloperoxidase at the Peak of Experimental Autoimmune Encephalomyelitis Restores Blood-Brain-Barrier Integrity and Ameliorates Disease Severity
- Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems
- Myeloperoxidase: Bridging the gap in neurodegeneration.
- Spinal Cord Inflammation: Molecular Imaging after Thoracic Aortic Ischemia Reperfusion Injury.
- In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis
- Myeloperoxidase: A new player in autoimmunity
- Neutrophils and redox stress in the pathogenesis of autoimmune disease.
- High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease
- Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon
- Molecular Imaging Unravels Cerebral Malaria.
- Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
- Multifunctional enzymatically-generated hydrogel platforms for chronic wound application
- MRI biomarkers of disease progression and conversion to secondary-progressive multiple sclerosis.
- Advances in Functional and Molecular MRI Technologies in Chronic Liver Diseases
- Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity
- The emerging role of neutrophils in autoimmune‐associated disorders: effector, predictor, and therapeutic targets
- d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation
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