Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas
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Summary
Genetic prevention of lymphoma in p53 knockout mice led to new models of sarcoma development, available for studies on hemangiosarcoma and osteosarcomas onset and metastatization.
- Type
- article
- Published
- 2014-11-18
- Cited by
- 12
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W25426555
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2749450
Keywords
Philosophy, Humanities, Art, Political science
References
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- New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.
- The first 30 years of p53: growing ever more complex
- Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program
- The ARF tumor suppressor: Structure, functions and status in cancer
- The ARF tumor suppressor can promote the progression of some tumors
- Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
- New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape
- Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.
- p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement
- INK4a/ARF inactivation with activation of the NF-κB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma
- Dysregulation of the mTOR pathway in p53-deficient mice
- Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.
- Animal Models in Osteosarcoma
- Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
- Osteosarcomagenesis: Modeling Cancer Initiation in the Mouse
Cited by
- Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse
- Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis
- HER2 isoforms co-expression differently tunes mammary tumor phenotypes affecting onset, vasculature and therapeutic response
- Survival rates of homozygotic Tp53 knockout rats as a tool for preclinical assessment of cancer prevention and treatment
- Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma
- Increased susceptibility to mammary carcinogenesis and an opposite trend in endometrium in Trp53 heterozygous knockout female mice by backcrossing the BALB/c strain onto the background C3H strain
- TP53 in bone and soft tissue sarcomas
- Comparaison anatomo-clinique des métastases pulmonaires de sarcome pédiatrique
- A Unique Spectrum of Spontaneous Tumors in Dino Knockout Mice Identifies Tissue-Specific Requirements for Tumor Suppression
- Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models
- Short report Open Access
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