Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy
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Summary
A clinically feasible and broadly applicable approach to limit immune costimulation to the disseminated tumor lesions of the patient, whereby an agonistic 4-1BB oligonucleotide aptamer is targeted to the tumor stroma by conjugation to an aptamer that binds to a broadly expressed stromal product, VEGF.
- Type
- article
- Published
- 2014-06-17
- Cited by
- 82
- References
- 104
- Access
- Open access
- OpenAlex
- https://openalex.org/W24938283
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20574926
Keywords
Cladding (metalworking), Rod, Embrittlement, Materials science, Boiling water reactor
References
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- Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors.
- CD27 is required for generation and long-term maintenance of T cell immunity
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- Enhanced Antitumor Responses Elicited by Combinatorial Protein Transfer of Chemotactic and Costimulatory Molecules1
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- CD27 and CD70 in T cell and B cell activation.
- Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
- Novel mAbs reveal potent co-stimulatory activity of murine CD27.
- Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.
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Cited by
- Functional‐DNA‐Driven Dynamic Nanoconstructs for Biomolecule Capture and Drug Delivery
- Aptamedicine: a new treatment modality in personalized cancer therapy
- Manipulating the in vivo immune response by targeted gene knockdown
- 4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity
- Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
- Reducing toxicity of 4–1BB costimulation: targeting 4–1BB ligands to the tumor stroma with bi-specific aptamer conjugates
- Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.
- Reducing Toxicity of Immune Therapy Using Aptamer-Targeted Drug Delivery
- An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy
- Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
- CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses
- Trends in the Design and Development of Specific Aptamers Against Peptides and Proteins
- Aptamers: A promising chemical antibody for cancer therapy
- Aptamer guided delivery of nucleic acid-based nanoparticles
- Engineering nanoparticles to overcome barriers to immunotherapy
- Tipping a favorable CNS intratumoral immune response using immune stimulation combined with inhibition of tumor-mediated immune suppression
- Chemical and Chemoenzymatic Synthesis of Outer Core Oligosaccharide of Escherichia Coli R3 and a Library of Human Milk Oligosaccharides & Design and Synthesis of Glycoconjugates
- MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells
- Prioritization schema for immunotherapy clinical trials in glioblastoma
- Immunotherapy in glioblastoma: emerging options in precision medicine.
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