In Depth Analysis of the Helicobacter pylori cag Pathogenicity Island Transcriptional Responses
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Summary
Light is shed on regulatory aspects of the cag-PAI, which may be involved in relevant molecular and etiological aspects of H. pylori pathogenesis, and it is demonstrated that the highly transcribed cagA oncogene is repressed by iron limitation through a direct apo-Fur regulation mechanism.
- Type
- article
- Published
- 2014-06-03
- Cited by
- 30
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W24892739
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:224180
Keywords
Traditional medicine, Humanities, Medicine, Philosophy
References
- FeON-FeOFF: the Helicobacter pylori Fur regulator commutates iron-responsive transcription by discriminative readout of opposed DNA grooves
- Architecture of the Helicobacter pylori Cag‐type IV secretion system
- Role of the cag pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis
- Helicobacter pylori–host cell interactions mediated by type IV secretion
- The Fur repressor controls transcription of iron‐activated and ‐repressed genes in Helicobacter pylori
- Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus
- HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar Typhimurium
- Detailed analysis of Helicobacter pylori Fur-regulated promoters reveals a Fur box core sequence and novel Fur-regulated genes
- Regulatory circuits in Helicobacter pylori : network motifs and regulators involved in metal-dependent responses.
- Helicobacter pylori Exploits a Unique Repertoire of Type IV Secretion System Components for Pilus Assembly at the Bacteria-Host Cell Interface
- Growth Phase and Metal-Dependent Transcriptional Regulation of the fecA Genes in Helicobacter pylori
- Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling.
- Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori
- Tyrosine-phosphorylated bacterial effector proteins: the enemies within.
- Gene expression in vivo shows that Helicobacter pylori colonizes an acidic niche on the gastric surface
- Strain-specific expression profiles of virulence genes in Helicobacter pylori during infection of gastric epithelial cells and granulocytes.
- Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori
- Built Shallow to Maintain Homeostasis and Persistent Infection: Insight into the Transcriptional Regulatory Network of the Gastric Human Pathogen Helicobacter pylori
- Protein-Protein Interactions among Helicobacter pylori Cag Proteins
- Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans.
Cited by
- Metalloregulation of Helicobacter pylori physiology and pathogenesis
- Relationship between Tobacco, cagA and vacA i1 Virulence Factors and Bacterial Load in Patients Infected by Helicobacter pylori
- Increasing transcriptome response of serpins during the ontogenetic stages in the salmon louse Caligus rogercresseyi (Copepoda: Caligidae).
- Improved method for extraction and detection of Helicobacter pylori DNA in formalin-fixed paraffin embedded gastric biopsies using laser micro-dissection
- The cag-pathogenicity island encoded CncR1 sRNA oppositely modulates Helicobacter pylori motility and adhesion to host cells
- Expression of cagA, virB/D Complex and/or vacA Genes in Helicobacter pylori Strains Originating from Patients with Gastric Diseases
- The effectiveness of a bundle in the prevention of ventilator-associated pneumonia
- Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome
- Transcriptional Profiling of Type II Toxin–Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967–HP0968 System
- Helicobacter pylori with East Asian-type cagPAI genes is more virulent than strains with Western-type in some cagPAI genes
- Functional characterization of the Helicobacter pylori Cag Type IV secretion system components CagH, CagI and CagL
- Gene Expression Profiling of Transcription Factors of Helicobacter pylori under Different Environmental Conditions
- An evaluation of selected oral health indicators and cariogenic bacteria titer in patients with Helicobacter pylori.
- Functional Cytotoxin Associated Gene A in Helicobacter pylori Strains and Its Association with Integrity of Cag -pathogenicity Island and Histopathological Changes of Gastric Tissue
- Dynamic Measures of Anxiety-Related Threat Bias: Links to Stress Reactivity
- Acid regulated gene expression of Helicobacter pylori: insight into acid protection and gastric colonization
- Prevalence of CagA and antimicrobial sensitivity of H. pylori isolates of patients with gastric cancer in Egypt
- The Helicobacter pylori Heat-Shock Repressor HspR: Definition of Its Direct Regulon and Characterization of the Cooperative DNA-Binding Mechanism on Its Own Promoter
- Effect of the cagW-based gene vaccine on the immunologic properties of BALB/c mouse: an efficient candidate for Helicobacter pylori DNA vaccine
- Regulatory networks of the T4SS control: from host cell sensing to the biogenesis and the activity during the infection.
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