Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution
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Summary
It is observed that CTLA4 blockade alone, and in particular in combination with PD1 blockade, is associated with an increased risk of symptomatic, sometimes severe, hypophysitis as well as thyroid dysfunction.
- Type
- article
- Published
- 2014-03-07
- Cited by
- 406
- References
- 14
- Access
- Open access
- OpenAlex
- https://openalex.org/W24610577
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12160843
Keywords
Motion (physics), Scope (computer science), Multidisciplinary approach, Animation, Motion capture
References
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
- CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production.
- Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.
- Endocrine side effects induced by immune checkpoint inhibitors.
- Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes
- B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
- Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model.
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer.
- Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma
- CTLA-4: new insights into its biological function and use in tumor immunotherapy
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- Autoimmune hypophysitis
- Autoimmune hypophysitis.
Cited by
- Group 3: Strategies for identifying the cause of adrenal insufficiency: diagnostic algorithms.
- Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms
- Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights
- Managing immune checkpoint-blocking antibody side effects.
- Ipilimumab‐induced hypophysitis in melanoma patients: an Australian case series
- Phase 1 Clinical Trial of Ipilimumab In Pediatric Patients With Advanced Solid Tumors
- Systemic high dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study
- Preventing peripheral intravenous catheter‐associated bloodstream infection: the randomised controlled trial versus the real world
- Impact of pneumococcal polysaccharide vaccine in people aged 65 years or older
- Realising the potential of the post‐2015 development agenda for Indigenous health
- Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review
- Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma.
- Immune-mediated Adverse Effects of Anti-CTLA-4 Antibody Therapy in Metastatic Melanoma
- Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies.
- Toxicities of Immunotherapy for the Practitioner.
- Radiographic Profiling of Immune-related Adverse Events in Advanced Melanoma Patients Treated With Ipilimumab
- HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis.
- Thyroid-Like Ophthalmopathy in a Euthyroid Patient Receiving Ipilimumab
- Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center
- Clinical Activity, Toxicity, Biomarkers, and Future Development of CTLA-4 Checkpoint Antagonists.
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