Effect of low extracellular pH on NF-κB activation in macrophages
Explore this paper's citation graph
Summary
A modest decrease in pH can sometimes have marked effects on NF-κB activation and cytokine secretion and might be one reason to explain why mice normally develop less atherosclerosis than do humans.
- Type
- article
- Published
- 2014-04-01
- Cited by
- 48
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W24530961
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30496115
Keywords
Hymenoptera, Geography, Ecology, Biology
References
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
- IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
- NF-kappaB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction
- An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China
- Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages1
- IKKε Knockout Prevents High Fat Diet Induced Arterial Atherosclerosis and NF-κB Signaling in Mice
- Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
- A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein Published, JLR Papers in Press, January 17, 2008.
- Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis.
- Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element ‘decoy’ of nuclear factor-kB binding site as a novel molecular strategy
- Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype.
- Does an acidic pH explain why low density lipoprotein is oxidised in atherosclerotic lesions?
- Molecular mechanisms of interleukin‐10‐mediated inhibition of NF‐κB activity: a role for p50
- Human serum, cysteine and histidine inhibit the oxidation of low density lipoprotein less at acidic pH
- Tissue pH Determination for the Detection of Metabolically Active, Inflamed Vulnerable Plaques Using Near-Infrared Spectroscopy: An in-vitro Feasibility Study
- Low extracellular pH stimulates the production of IL-1β by human monocytes.
- Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding.
- Post-transcriptional effects of extracellular pH on tumour necrosis factor-alpha production in RAW 246.7 and J774 A.1 cells.
- Lipid oxidation predominates over protein hydroperoxide formation in human monocyte-derived macrophages exposed to aqueous peroxyl radicals
- Progress and challenges in translating the biology of atherosclerosis
Cited by
- Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations.
- Accelerated Vascular Disease in Systemic Lupus Erythematosus: Role of Macrophage
- Mesenchymal stem cells alleviate atherosclerosis by elevating number and function of CD4+CD25+FOXP3+ regulatory T-cells and inhibiting macrophage foam cell formation
- Acidification of the intimal fluid: the perfect storm for atherogenesis
- Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis
- Interleukin-1 signalling in disease
- Correlation between mimecan expression and coronary artery stenosis in patients with coronary heart disease.
- A novel pentacyclic triterpenoid, Ilexgenin A, shows reduction of atherosclerosis in apolipoprotein E deficient mice.
- Engineered Proteins Program Mammalian Cells to Target Inflammatory Disease Sites.
- Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels
- Étude génétique et fonctionnelle des gènes de la région 14q31 associée aux maladies inflammatoires de l’intestin
- Original Article Correlation between mimecan expression and coronary artery stenosis in patients with coronary heart disease
- Acidosis exacerbates in vivo IL-1-dependent inflammatory responses and neutrophil recruitment during pulmonary Pseudomonas aeruginosa infection.
- Sodium bicarbonate regulates nitric oxide production in mouse macrophage cell lines stimulated with lipopolysaccharide and interferon γ.
- Axl Involved in Mineral Trioxide Aggregate Induces Macrophage Polarization
- Unravelling the Interplay between Extracellular Acidosis and Immune Cells
- Comparison of adipose- and bone marrow-derived stem cells in protecting against ox-LDL-induced inflammation in M1-macrophage-derived foam cells
- Physicochemical characterization of barrier membranes for bone regeneration.
- Functional regeneration of tissue engineered skeletal muscle in vitro is dependent on the inclusion of basement membrane proteins
- A comparable study of polyglycolic acid's degradation on macrophages' activation.
Related papers
- New records of Diapriinae (Hymenoptera, Diapriidae) for Turkey.
- A study of the rare genus Gnamptodon Haliday (Hymenoptera: Braconidae: Gnamptodontinae) in Iran, with three new records.
- Further records of Irish Pteromalidae (Hymenoptera: Chalcidoidea), including ten species new to Ireland.
- Japanese species of Trigonoderus (Hymenoptera, Pteromalidae) with descriptions of three new species.
- Diversity and new distributional records of fairyflies (Hymenoptera: Chalcidoidea: Mymaridae) from the State of Kerala, India.
- A contribution to the knowledge of the eastern Mediterranean Myzinidae I. Subfamily Mesinae (Hymenoptera, Aculeata).
- Notes on two genera of Microteryini new to China. Descriptions of with two new species (Hymenoptera: Encyrtidae).
- A new record species of Ablerus Howard (Hymenoptera, Aphelinidae) from China.
- Study of Peninsular Ichneumoninae of the National Museum of Natural Sciences. Phaeogenini (Hymenoptera: Ichneumonidae).
- A review of the Irish platygastrids (Hymenoptera: Platygastroidea, Platygastridae) including their known distributions.