Quel avenir pour les médicaments de l’hémostase dans le traitement du sepsis sévère après le Xigris® ?
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Summary
Activated protein C, like other coagulation inhibitors, possesses anti-inflammatory properties in addition to their anticoagulant activity, making them attractive candidates in this indication.
- Type
- article
- Published
- 2013-02-08
- Cited by
- 1
- References
- 75
- OpenAlex
- https://openalex.org/W24527291
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:159908962
Keywords
Molecular biology, Medicine, Philosophy, Biology
References
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- Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats.
- Clinical features and outcomes of 35 disseminated intravascular coagulation cases treated with recombinant human soluble thrombomodulin at a single institution.
- Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis
- Activated protein C: from structure/function relationship to the design of recombinant proteins with targeted activities
- Efficacy and safety of recombinant human soluble thrombomodulin (ART‐123) in disseminated intravascular coagulation: results of a phase III, randomized, double‐blind clinical trial
- An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia.
- Blockade of tissue factor: treatment for organ injury in established sepsis.
- Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation
- Dose–response study of recombinant human soluble thrombomodulin (ART‐123) in the prevention of venous thromboembolism after total hip replacement
- Effects of a Low Molecular Weight Heparin, Bemiparin, and Unfractionated Heparin on Hemostatic Properties of Endothelium
- The effect of heparin administration in animal models of sepsis: A prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies
- Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates
- AGE-SPECIFIC INCIDENCE AND OUTCOME OF SEPSIS IN THE US
- A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome*
- Factor XI Deficiency
- Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis.
- Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study.
- A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome
- Phase I study of a novel recombinant human soluble thrombomodulin, ART‐123
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