Nucleosomes accelerate transcription factor dissociation
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Summary
The results suggest that TF binding within chromatin could be responsible for the dramatic increase in TF exchange in vivo and demonstrate that nucleosomes regulate DNA–protein interactions not only by preventing DNA– protein binding but by dramatically increasing the dissociation rate of protein complexes from their DNA-binding sites.
- Type
- article
- Published
- 2013-12-17
- Cited by
- 122
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W24353316
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15457902
Keywords
Humanities, Art, Philosophy
References
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Cited by
- DNA-segment-facilitated dissociation of Fis and NHP6A from DNA detected via single-molecule mechanical response
- “Hit-and-Run” leaves its mark: Catalyst transcription factors and chromatin modification
- Many-body effects on tracer particle diffusion with applications for single-protein dynamics on DNA
- Demystifying PIFE: The Photophysics Behind the Protein-Induced Fluorescence Enhancement Phenomenon in Cy3.
- Post-Translational Modifications of Histones That Influence Nucleosome Dynamics
- Histone variants at the transcription start-site.
- Absence of a simple code: how transcription factors read the genome
- ChIP-Array 2: integrating multiple omics data to construct gene regulatory networks
- Stochastic Ratchet Mechanisms for Replacement of Proteins Bound to DNA
- Quantitative models for accelerated protein dissociation from nucleosomal DNA
- Dynamic regulation of transcription factors by nucleosome remodeling
- Single Molecule Fluorescence Methodologies for Investigating Transcription Factor Binding Kinetics to Nucleosomes and DNA
- Theoretical estimates of exposure timescales of protein binding sites on DNA regulated by nucleosome kinetics
- Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging*♦
- Dynamic Chromatin Regulation from a Single Molecule Perspective.
- Linker histone H1 and H3K56 acetylation are antagonistic regulators of nucleosome dynamics
- Facilitated Dissociation of a Nucleoid Protein from the Bacterial Chromosome
- Metagenomic analysis of rapid gravity sand filter microbial communities suggests novel physiology of Nitrospira spp.
- The Chd1 chromatin remodeler can sense both entry and exit sides of the nucleosome
- Role of transcription factor-mediated nucleosome disassembly in PHO5 gene expression
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