N-myc Downstream-regulated Gene 1 Promotes Tumor Inflammatory Angiogenesis through JNK Activation and Autocrine Loop of Interleukin-1α by Human Gastric Cancer Cells*
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Summary
NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation and could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.
- Type
- article
- Published
- 2013-07-11
- Cited by
- 45
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W23846687
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11493644
Keywords
Liability, Business, Actuarial science, Accounting
References
- Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity.
- Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.
- The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis1
- The Drg-1 gene suppresses tumor metastasis in prostate cancer.
- Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.
- Metastasis Suppressor Genes: At the Interface Between the Environment and Tumor Cell Growth
- Localization of N-myc downstream-regulated gene 1 in gastric cancer tissue.
- Metastasis suppressor genes: From gene identification to protein function and regulation
- Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor.
- Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.
- Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.
- Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells
- Is interleukin‐1 a good or bad ‘guy’ in tumor immunobiology and immunotherapy?
- KAI1 Gene Is Engaged in NDRG1 Gene-mediated Metastasis Suppression through the ATF3-NFκB Complex in Human Prostate Cancer*
- Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma.
- Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
- Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer
- Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression
- Establishment of Lipopolysaccharide-dependent Nuclear Factor κB Activation in a Cell-free System (*)
- N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells through Epithelial Mesenchymal Transition
Cited by
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- NDRG1 overexpressing gliomas are characterized by reduced tumor vascularization and resistance to antiangiogenic treatment.
- The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling.
- Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.
- Inflammation, a key factor in cancer ambush
- Suppression of IL‐8‐Src signalling axis by 17β‐estradiol inhibits human mesenchymal stem cells‐mediated gastric cancer invasion
- Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice
- Interleukin 1α and the inflammatory process
- Ndrg1 promotes adipocyte differentiation and sustains their function
- NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy
- FOXQ1/NDRG1 axis exacerbates hepatocellular carcinoma initiation via enhancing crosstalk between fibroblasts and tumor cells.
- Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- Function and regulation of IL-1α in inflammatory diseases and cancer
- mTOR at the Transmitting and Receiving Ends in Tumor Immunity
- CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1α/VEGF-A pathway in colorectal cancer
- NDRG1 negatively regulates proliferation and Milk bio-synthesis of bovine epithelial cells via the mTOR signaling pathway.
- Hormonally induced defects of DNA damage repair genes: an oncogenic driver of prostate cancer
- Involvement of multiple transcription factors in regulation of IL-β-induced MCP-1 expression in alveolar type II epithelial cells.
- Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer.
- IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis