DNA Methylation Patterns Facilitate the Identification of MicroRNA Transcription Start Sites: A Brain-Specific Study
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Summary
This model achieves an accuracy of more than 80% and establishes the potential of epigenetic analysis for in silico prediction of TSSs of brain-specific miRNAs by using epigenetic as well as genetic features to predict the primary transcripts.
- Type
- article
- Published
- 2013-06-24
- Cited by
- 10
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W23826117
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6707145
Keywords
Political science
References
- Pattern Classification
- Epigenomics: genome-wide study of methylation phenomena.
- Galaxy, a web-based genome analysis tool for experimentalists
- Genomic analysis of human microRNA transcripts
- Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data
- Epigenetic Islands in a Genetic Ocean
- Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation
- Comprehensive analysis of CpG islands in human chromosomes 21 and 22
- Chromatin structure analyses identify miRNA promoters.
- miRT: A Database of Validated Transcription Start Sites of Human MicroRNAs
- An Analysis of Human MicroRNA and Disease Associations
- Identification and analysis of transcription factor family-specific features derived from DNA and protein information
- CpG islands: algorithms and applications in methylation studies
- The potential functions of primary microRNAs in target recognition and repression
- An Improved Maximum Relevance and Minimum Redundancy Feature Selection Algorithm Based on Normalized Mutual Information
- Human DNA methylomes at base resolution show widespread epigenomic differences
- MethylomeDB: a database of DNA methylation profiles of the brain
- Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia.
- miRBase: tools for microRNA genomics
- CpG islands in vertebrate genomes.
Cited by
- Epigenetic Programming of Hypoxic-Ischemic Encephalopathy in Response to Fetal Hypoxia
- Epigenetics and Epilepsy.
- Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy
- Epigenetic Interventions for Epileptogenesis: A New Frontier for Curing Epilepsy
- Unsupervised Feature Selection Using an Integrated Strategy of Hierarchical Clustering With Singular Value Decomposition: An Integrative Biomarker Discovery Method With Application to Acute Myeloid Leukemia
- Comparison of five supervised feature selection algorithms leading to top features and gene signatures from multi-omics data in cancer
- Soft Computing for Biological Systems
- Unsupervised Feature Selection Using Iterative Shrinking and Expansion Algorithm
- Study on MiRNA Epigenetic Intervention for Epilepsy
- Module-Based Knowledge Discovery for Multiple-Cytosine-Variant Methylation Profile
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