Development and characterization of a high-throughput in vitro cord formation model insensitive to VEGF inhibition
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Summary
The in vitro approach is used to develop an in vivo co-implant vasculogenesis model that connects with the endogenous vasculature to form functional blood vessels that become insensitive to VEGF inhibition over time.
- Type
- article
- Published
- 2013-04-27
- Cited by
- 21
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W23622716
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2626876
Keywords
Computer science
References
- Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
- Role of pericytes in vascular morphogenesis.
- Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody.
- Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
- Chapter 13. An in vivo experimental model for postnatal vasculogenesis.
- Comparison of three in vitro human ‘angiogenesis’ assays with capillaries formed in vivo
- An in vitro model of angiogenesis: Basic features
- Dual Targeting of Tumor Vasculature: Combining Avastin and Vascular Disrupting Agents (CA4P or OXi4503)
- Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
- Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors
- Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
- Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels.
- Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
- Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.
- Adipose Tissue Progenitor Cells Directly Interact with Endothelial Cells to Induce Vascular Network Formation
- Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.
- Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research.
- Mural Cell Associated VEGF Is Required for Organotypic Vessel Formation
- Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
- VEGF-targeted therapy: mechanisms of anti-tumour activity
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- An In Vitro Cord Formation Assay Identifies Unique Vascular Phenotypes Associated with Angiogenic Growth Factors
- Consideration of the cellular microenvironment: physiologically relevant co-culture systems in drug discovery.
- A Method to Assess Target Gene Involvement in Angiogenesis In Vitro and In Vivo Using Lentiviral Vectors Expressing shRNA
- Human iPSC-Derived Endothelial Cell Sprouting Assay in Synthetic Hydrogel Arrays
- An Endothelial Cell/Mesenchymal Stem Cell Coculture Cord Formation Assay to Model Vascular Biology In Vitro.
- Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment
- Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy
- Gold nanorod based delivery system could bring about superior therapy effect of Ramucirumab through direct cytotoxicity to cancer cell mediated by differential regulation of phagocytosis in gastric cancer cell
- Molecular mechanisms of synergistic action of Ramucirumab and Paclitaxel in Gastric Cancers cell lines
- Understanding the Role of Innate Immune Cells and Identifying Genes in Breast Cancer Microenvironment
- Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors
- Gold nanoparticles enhance antibody effect through direct cancer cell cytotoxicity by differential regulation of phagocytosis
- Efficacy and safety evaluations of anlotinib in patients with advanced non-small cell lung cancer treated with bevacizumab
- The Expression and Correlation of Pin1 and VEGF in Lung Cancer
- PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies
- Multimode Ultrasound Model for Predicting the Early Treatment Response of Anti-VEGF Agents Plus Anti-PD-1 Antibody in Patients with Unresectable Hepatocellular Carcinoma.
- Adverse reactions of immune checkpoint inhibitors combined with angiogenesis inhibitors: A pharmacovigilance analysis of drug–drug interactions
- Vascularized in vitro bone model as 3D quadruple culture with primary human osteoblasts, osteocytes, osteoclasts and endothelial cells
- Cancer-Immunity Cycle-Based Smart Nucleic Acid Nanodrugs for Potentiated Immunotherapy
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