Genetic Evidence for p75NTR-Dependent Tetraploidy in Cortical Projection Neurons from Adult Mice
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Summary
An optimized flow cytometric assay is used, based on the analysis of unfixed brain cell nuclei, to study whether p75NTR-dependent neuronal tetraploidization takes place in the cerebral cortex, giving rise to projection neurons as well, and concludes that tetRAploidy mainly affects long-range projection neurons, being facilitated by p 75NTR in the neocortex.
- Type
- article
- Published
- 2013-04-24
- Cited by
- 35
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W23616554
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5725712
Keywords
Computer science
References
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Cited by
- Flow cytometric analysis of DNA synthesis and apoptosis in central nervous system using fresh cell nuclei.
- Neuronal cell cycle: the neuron itself and its circumstances
- Characterization of brain cell nuclei with decondensed chromatin
- p27Kip1 participates in the regulation of endoreplication in differentiating chick retinal ganglion cells
- Brain-Derived Neurotrophic Factor-Dependent cdk1 Inhibition Prevents G2/M Progression in Differentiating Tetraploid Neurons
- The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth
- Introduction of macarpine as a novel cell‐permeant DNA dye for live cell imaging and flow cytometry sorting
- Proneurotrophin-3 promotes cell cycle withdrawal of developing cerebellar granule cell progenitors via the p75 neurotrophin receptor
- Eph-mediated tyrosine phosphorylation of citron kinase controls abscission
- Effects of whole genome duplication on cell size and gene expression in mouse embryonic stem cells
- Cell Cycle Analysis in the Vertebrate Brain Using Immunolabeled Fresh Cell Nuclei
- Gene regulation and genetics in neurochemistry, past to future
- Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology.
- Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting
- Polyploidy and the Cellular and Areal Diversity of Rat Cortical Layer 5 Pyramidal Neurons.
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- Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons
- Cell-type-specific epigenetics of organ-derived neurons and adipocytes
- Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification
- Polyploidy in the adult Drosophila brain
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