Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism.
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Summary
There is a strong evidence for alterations in metabolic pathways caused by B[a]P exposure in stimulated cells, and the proteome changes in unstimulated cells point towards a modified regulation of the cytoskeleton and cellular stress response.
- Type
- article
- Published
- 2013-06-15
- Cited by
- 17
- References
- 68
- OpenAlex
- https://openalex.org/W23583300
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29750339
Keywords
Humanities, Medicine, Philosophy
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Cited by
- The Protective Effect of Dietary Arthrospira (Spirulina) maxima Against Mutagenicity Induced by Benzo[alpha]pyrene in Mice
- Mass spectrometry data from proteomics-based screening of immunoreactive proteins of fully virulent Brucella strains using sera from naturally infected animals
- (−)‐Epigallocatechin‐3‐Gallate Ameliorates Photodynamic Therapy Responses in an In Vitro T Lymphocyte Model
- Characterization of the native C-reactive protein (cCRP) and the corresponding liver mRNA in dogs.
- Proteomics-based identification of immunodominant proteins of Brucellae using sera from infected hosts points towards enhanced pathogen survival during the infection.
- Tea Catechins Inhibit Cell Proliferation Through Hydrogen Peroxide-Dependent and -Independent Pathways in Human T lymphocytic Leukemia Jurkat Cells
- Tert-Butylhydroquinone as a Phenolic Activator of Nrf2 Antagonizes Arsenic-Induced Oxidative Cytotoxicity but Promotes Arsenic Methylation and Detoxication in Human Hepatocyte Cell Line
- Subtoxic and toxic concentrations of benzene and toluene induce Nrf2‐mediated antioxidative stress response and affect the central carbon metabolism in lung epithelial cells A549
- The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells.
- Comprehensive Identification of Immunodominant Proteins of Brucella abortus and Brucella melitensis Using Antibodies in the Sera from Naturally Infected Hosts
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- Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
- Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing
- Responses of human hepatoma HepG2 cells to silver nanoparticles and polycyclic aromatic hydrocarbons
- Identification of Chitinase-3-Like Protein 1 as a Novel Neutrophil Antigenic Target in Crohn’s Disease
- Targeted metabolomics analysis identified the role of FOXA1 in the change in glutamate-glutamine metabolic pattern of BaP malignantly transformed 16HBE cells.
- Assessment of Composite Immunotoxicity of Yangtze River Water Extracts Using Multiendpoint In Vitro Bioassays
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