Nucleus pulposus degeneration alters properties of resident progenitor cells
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Summary
It is concluded that IVD degeneration has a meaningful effect on the cells in the NP, and although both cell types are able to differentiate into mesenchymal lineages, H- NP cells exhibit significantly greater differentiation toward the chondrogenic lineage and NP-like cells than D-NP cells, displaying greater production of glycosaminoglycans and higher gene expression of aggrecan and collagen IIa.
- Type
- article
- Published
- 2013-04-09
- Cited by
- 63
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W23578990
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:708339
Keywords
Flammable liquid, Isobutane, Propane, Butane, Gasoline
References
- Differentiation of Mesenchymal Stem Cells Towards a Nucleus Pulposus-like Phenotype In Vitro: Implications for Cell-Based Transplantation Therapy
- Osteogenic and adipogenic differentiation potential of an immortalized fibroblast-like cell line derived from porcine peripheral blood
- Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc.
- Stem Cells Units of Development, Units of Regeneration, and Units in Evolution
- Human disc cells in monolayer vs 3D culture: cell shape, division and matrix formation
- Adequacy of herniated disc tissue as a cell source for nucleus pulposus regeneration.
- Motor Neuron Degeneration Promotes Neural Progenitor Cell Proliferation, Migration, and Neurogenesis in the Spinal Cords of Amyotrophic Lateral Sclerosis Mice
- Osteogenic Differentiation of Noncultured Immunoisolated Bone Marrow‐Derived CD105+ Cells
- Behavior of Human Articular Chondrocytes Derived from Nonarthritic and Osteoarthritic Cartilage in a Collagen Matrix
- The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo.
- Degenerative Changes of Porcine Intervertebral Disc Induced by Vertebral Endplate Injuries
- Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis.
- Chondrogenic Potential of Human Adult Mesenchymal Stem Cells Is Independent of Age or Osteoarthritis Etiology
- Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region: A Study in Four Species
- The cell biology of intervertebral disc aging and degeneration.
- Mesenchymal stem cell: use and perspectives.
- Mesenchymal stem cells in arthritic diseases
- Molecular phenotypes of notochordal cells purified from immature nucleus pulposus
- Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure.
- A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation.
Cited by
- Scanning pattern of diffusion tensor tractography and an analysis of the morphology and function of spinal nerve roots
- Stem Cell Approaches to Intervertebral Disc Regeneration: Obstacles from the Disc Microenvironment
- Effects of resting modes on human lumbar spines with different levels of degenerated intervertebral discs: a finite element investigation
- TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling
- Coming together is a beginning: the making of an intervertebral disc.
- Annulus Fibrosus Cell Characteristics Are a Potential Source of Intervertebral Disc Pathogenesis
- Matrix stiffness determines the fate of nucleus pulposus-derived stem cells.
- Potential and limitations of intervertebral disc endogenous repair.
- Mesenchymal stem cells: potential application in intervertebral disc regeneration.
- Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation
- MiR-221 Attenuates the Osteogenic Differentiation of Human Annulus Fibrosus Cells
- Stem cell matrix and cartilage regeneration
- BMP7-Based Functionalized Self-Assembling Peptides Protect Nucleus Pulposus-Derived Stem Cells From Apoptosis In Vitro
- A Global Pictorial Assessment of theIntervertebral Disc Cell in Several SpeciesReveals a Remarkable Biodiversity in this Cell Type which should be taken into Account in Experimental Studies on Intervertebral Disc Repair
- Human Induced Pluripotent Stem Cells Differentiate Into Functional Mesenchymal Stem Cells and Repair Bone Defects
- Cell technologies in treatment of human intervertebral disc: perspectives
- Cell properties of nucleus pulposus progenitor cells declines with intervertebral disc degeneration
- The Role of Cell Clusters in Intervertebral DiscDegeneration and its Relevance behind Repair
- Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies.
- Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence
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