Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain
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Summary
The results reveal that brain aging is accompanied with a significant increase in NADPH oxidase activity and mitochondrial ROS production, a distinct elevation of IL-1β, IL-6 and TNF-α levels along with increased nuclear translocation of NF-κβ (p65 subunit) and all these phenomena are partially but significantly prevented by the long-term dietary antioxidant treatment.
- Type
- article
- Published
- 2012-08-01
- Cited by
- 40
- References
- 54
- OpenAlex
- https://openalex.org/W22851277
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7109894
Keywords
Robustness (evolution), Test (biology), Economics, Business, Finance
References
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- Age-related oxidative inactivation of Na+, K+-ATPase in rat brain crude synaptosomes.
- Dietary supplementation with N-acetylcysteine, α-tocopherol and α-lipoic acid prevents age related decline in Na+,K+-ATPase activity and associated peroxidative damage in rat brain synaptosomes
- Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells.
- On the importance of fatty acid composition of membranes for aging.
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- IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase
- Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
- Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses.
- Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor κB
Cited by
- Efeitos in vitro do ácido pipecólico sobre parâmetros de estresse oxidativo e a possível prevenção pelo ácido lipoico em córtex cerebral de ratos
- Lipoic acid and N-acetylcysteine prevent ammonia-induced inflammatory response in C6 astroglial cells: The putative role of ERK and HO1 signaling pathways.
- Atividade antioxidante, anticolinesterásica e perfil metabolômico de diferentes tipos de pimentas: Implicações na doença de Alzheimer
- The Oral Iron Chelator, Deferasirox, Reverses the Age-Dependent Alterations in Iron and Amyloid-β Homeostasis in Rat Brain: Implications in the Therapy of Alzheimer’s Disease
- Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol.
- Inhibitory effects of indole α‐lipoic acid derivatives on nitric oxide production in LPS/IFNγ activated RAW 264.7 macrophages
- Dihydrolipoyl dehydrogenase as a potential UVB target in skin epidermis; using an integrated approach of label-free quantitative proteomics and targeted metabolite analysis.
- Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats.
- Long-term cysteine fortification impacts cysteine/glutathione homeostasis and food intake in ageing rats
- Multiple Mechanisms of Iron-Induced Amyloid Beta-Peptide Accumulation in SHSY5Y Cells: Protective Action of Negletein
- Antidepressant-like effect of α-tocopherol in a mouse model of depressive-like behavior induced by TNF-α.
- L-Cysteine metabolism and its nutritional implications.
- Cell ageing: a flourishing field for neurodegenerative diseases
- Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators.
- Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: the NF-κB connection.
- Oxidative stress and amyloid beta toxicity in Alzheimer's disease: intervention in a complex relationship by antioxidants.
- Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis
- Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice
- Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats
- Daily supplementation with GrandFusion® improves memory and learning in aged rats
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